Review in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
19 authors.
Mateusz LabuddaDepartment of Biochemistry and Microbiology, Institute of Biology, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.ORCID 0000-0001-8014-1644
Anna Rybarczyk-PłońskaDepartment of Biochemistry and Microbiology, Institute of Biology, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.ORCID 0000-0002-4151-0467
Kamil Aleksander SobieszekFaculty of Medicine, Jagiellonian University Medical College, Jagiellonian University, Św. Anny 12, 31-008 Krakow, Poland.ORCID 0009-0007-4426-2554
Tomasz NiedzińskiDivision of Agricultural and Environmental Chemistry, Institute of Agriculture, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.ORCID 0000-0002-4892-5606
Wesley Borges WurlitzerLaboratory of Acarology, Tecnovates, University of Vale do Taquari-Univates, Lajeado 95914-014, RS, Brazil.ORCID 0000-0003-3749-2355
Ewa MuszyńskaSection of Plant Physiology and Biochemistry, Polish Botanical Society, Ujazdowskie 4, 00-478 Warsaw, Poland.ORCID 0000-0003-0419-4597
Beata PrabuckaDepartment of Biochemistry and Microbiology, Institute of Biology, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.ORCID 0000-0001-8429-5114
Szymon FlorczakDepartment of Biochemistry and Microbiology, Institute of Biology, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.ORCID 0000-0001-6111-5117
Monika TomczykowaDepartment of Organic Chemistry, Faculty of Medicine with the Division of Dentistry and Division of Medical Education in English, Medical University of Białystok, Mickiewicza 2a, 15-222 Białystok, Poland.ORCID 0000-0002-4894-7557
Wojciech MakowskiSection of Plant Physiology and Biochemistry, Polish Botanical Society, Ujazdowskie 4, 00-478 Warsaw, Poland.ORCID 0000-0001-9662-5467
Jakub GraskaDepartment of Biochemistry and Microbiology, Institute of Biology, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.ORCID 0000-0002-1295-5248
Jakub FrankowskiSchool of Medical and Health Sciences, VIZJA University, Okopowa 59, 01-043 Warsaw, Poland.ORCID 0000-0003-1657-9283
Paulina KęszyckaDepartment of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-787 Warsaw, Poland.ORCID 0000-0003-1302-9171
Danuta GajewskaDepartment of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-787 Warsaw, Poland.ORCID 0000-0002-3071-7593
Abdelfattah A DababatSoil Borne Pathogens Program, International Maize and Wheat Improvement Center (CIMMYT-Türkiye), Cem Erserver Caddesi No: 9-11 Yenimahalle, 06810 Ankara, Türkiye.ORCID 0000-0002-3172-0452
Iwona MorkunasDepartment of Plant Physiology, Faculty of Agriculture, Horticulture and Biotechnology, Poznań University of Life Sciences, Wołyńska 35, 60-637 Poznań, Poland.
Joanna TrafiałekDepartment of Food Gastronomy and Food Hygiene, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.ORCID 0000-0001-5839-1786
Michał TomczykDepartment of Biology and Pharmacognosy, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Białystok, Mickiewicza 2a, 15-222 Białystok, Poland.ORCID 0000-0002-4063-1048
Michał CzaplaDivision of Scientific Research and Innovation in Emergency Medical Service, Department of Emergency Medical Service, Faculty of Nursing and Midwifery, Wroclaw Medical University, Parkowa 34, 51-618 Wroclaw, Poland.ORCID 0000-0002-4245-5420
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
BACKGROUND/
objectivesGlucosinolates (GSLs) from cruciferous vegetables (CVs), sulfur (S)- and nitrogen-containing compounds, are enzymatically hydrolyzed by myrosinase (EC 3.2.1.147) to yield bioactive derivatives such as isothiocyanates (ITCs) and indoles. These metabolites exhibit chemopreventive and anticancer properties. The article compiles evidence regarding the following: (i) the molecular mechanisms regulating the biosynthesis of key derivatives, including sulforaphane (SFN), phenethyl isothiocyanate (PEITC), and indole-3-carbinol (I3C); (ii) epidemiological and clinical findings; and (iii) strategies to link plant science with nutritional interventions for cancer prevention.
methodsAn integrative literature review was conducted using Web of Science, Scopus, ScienceDirect, Google Scholar, and PubMed. English-language studies addressing mechanistic insights, nutritional factors, epidemiology, and clinical trials were included.
resultsThe biosynthesis and metabolism of GSL in plants are regulated by S and several transcription factors that promote or repress GSL production. Additionally, food processing has been shown to influence retention time and the formation of ITCs. In humans, ITCs activate nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated detoxification, induce apoptosis, and modulate epigenetic pathways. Epidemiological data show inverse associations between CV intake and cancer risk, though variability exists. Clinical trials have confirmed the bioavailability and effects of glucoraphanin and SFN on cancer-related biomarkers.
conclusionsThe described compounds are bioavailable in humans and modulate the clinically relevant pathways linked to carcinogenesis. Larger, standardized interventions are needed to determine effective intake levels, optimize bioavailability, and define their potential role in evidence-based nutritional strategies for cancer prevention.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
The Chemopreventive and Anticancer Potential of Glucosinolates and Their Hydrolysis Products from Cruciferous Vegetables. · full record | Socratic