ArticleNutrients2026
Synergistic Effects of Nutritional Formula on Joint Inflammation Through Modulation of Bone Metabolism in Rats.
Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundJoint inflammation is significantly connected with progressive joint deterioration, potentially increasing the incidence of persistent major clinical challenges and global disability. Nutrient-based preventive strategies have been explored to investigate the interventive efficacy of the proposed prescribed formula for joint inflammation. However, the synergistic ameliorative effects of the nutritional formula should be evaluated to investigate its impact on joint inflammation.
methodsA prescribed formula including turmeric (T),
resultsThe prescribed formula was shown to synergistically reduce levels of inflammation-related cytokines, reduce oxidative stress, and enhance bone metabolism to promote joint regeneration. Micro-Computed Tomography (Micro-CT) analysis revealed restoration of joint architecture and ameliorated physiological status upon formula intervention. In vitro analysis further validated the synergistic alleviation of inflammation and oxidation, as well as reductions in MMP13 and CTX-1 levels, which implies that modulating bone metabolism alleviates the deterioration and inflammation of joint architecture.
conclusionsThe synergistic formula in this study achieves synchronous modulation of several core pathological pathways, yielding synergistic modulation of joint inflammation. Nutrient-based interventions or preventive strategies show promising effects against joint inflammation and progressive mechanistic deterioration.
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