Evidence map›Paper›PMID 41829977›Full record

SynthesisNutrients2026

Post-Diagnosis Adherence to the Mediterranean Diet and Cancer Recurrence and Fatigue Outcomes in Cancer Survivors, with Emphasis on Colorectal Cancer: A Systematic Review and Meta-Analysis.

Dimitris Papamichael, Kyriacos Felekkis, Eleni P Andreou

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dimitris PapamichaelDepartment of Life Sciences, School of Life and Health Sciences, University of Nicosia, 46 Makedonitisas Avenue, Nicosia CY1700, Cyprus.ORCID 0009-0005-7306-427X
Kyriacos FelekkisDepartment of Life Sciences, School of Life and Health Sciences, University of Nicosia, 46 Makedonitisas Avenue, Nicosia CY1700, Cyprus.
Eleni P AndreouDepartment of Life Sciences, School of Life and Health Sciences, University of Nicosia, 46 Makedonitisas Avenue, Nicosia CY1700, Cyprus.ORCID 0000-0002-0449-6782

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer survivors face heightened risks of recurrence and persistent cancer-related fatigue (CRF), both of which impair quality of life. The Mediterranean Diet (MD), characterized by its antioxidant and anti-inflammatory profile, has been proposed as a potentially beneficial dietary pattern. This systematic review and meta-analysis evaluated the association between post-diagnosis MD adherence and outcomes of cancer recurrence and CRF among adult survivors, with particular attention to colorectal cancer.

methodsSystematic searches of PubMed, CINAHL, and the Cochrane Library (January 1995-May 2024) identified prospective cohort studies and randomized controlled trials (RCTs) reporting post-diagnosis MD adherence. Primary outcomes were cancer recurrence and CRF. Random-effects models were applied for recurrence analyses due to anticipated heterogeneity, while a fixed-effects model was used for CRF given the limited number of trials. Heterogeneity was assessed using the

resultsEight studies met inclusion criteria: six prospective cohort studies assessed recurrence (

conclusionsHigher adherence to the Mediterranean Diet after cancer diagnosis was associated with recurrence-related outcomes in observational studies, while evidence for CRF remains exploratory and statistically imprecise. Larger, adequately powered randomized trials are needed to clarify the role of the Mediterranean Diet in survivorship care.

Indexed as

Cancer SurvivorsColorectal NeoplasmsDiet, MediterraneanFatigueNeoplasm Recurrence, LocalPatient ComplianceFemaleHumansMaleQuality of LifeRandomized Controlled Trials as Topiccancer recurrencecancer-related fatiguecancer survivorscolorectal cancermediterranean dietnutritionsurvivorship

Identifiers

PMID41829977
PMCPMC12987049

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.