ArticleTheScientificWorldJournal2026
Bidara Upas Leaf Extract (Merremia mammosa) as a Therapy to Enhance Pulmonary Macrophage Cells in Mice Infected With Mycobacterium tuberculosis.
Article in TheScientificWorldJournal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Bidara Upas Leaf Extract (Merremia mammosa) as a Therapy to Enhance Pulmonary Macrophage Cells in Mice Infected With Mycobacterium tuberculosis.TheScientificWorldJournal · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Tuberculosis (TB) is a serious infection caused by Mycobacterium tuberculosis, primarily affecting the lungs and spreading through the air. Each year, approximately 10 million new TB cases are reported worldwide, with Indonesia ranking third in the highest number of TB cases. TB treatment faces challenges due to drug resistance, such as MDR-TB and XDR-TB, which drives research into alternative therapies, one of which is the extract of Merremia mammosa, known for its antibacterial and immunomodulatory potential. This study is aimed at evaluating the potential of Merremia mammosa extract in enhancing immune responses, particularly through lung macrophages, in mice infected with M. tuberculosis. The research was conducted at the Integrated Laboratory of the Poltekkes Kemenkes Surabaya, from March to December 2024. Mice were divided into treatment and control groups, receiving extracts at varying doses after TB bacteria injection. The results indicated that Merremia mammosa extract could reduce lung cell necrosis, with the treatment groups showing lower levels of necrosis compared to the positive control group. The P13 and P12 treatment groups showed the best results, with minimal to no necrosis, indicating the potential therapeutic effects of the extract in improving lung tissue. Appropriate dose adjustments are necessary for optimal lung protection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.