ArticleBioMed research international2026
Usefulness of Molecular Diagnostic Kits for Detecting Helicobacter pylori Infection in Patients Receiving Proton Pump Inhibitors and Potassium-Competitive Acid Blockers.
Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Usefulness of Molecular Diagnostic Kits for Detecting Helicobacter pylori Infection in Patients Receiving Proton Pump Inhibitors and Potassium-Competitive Acid Blockers.BioMed research international · 2026Article
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15 authors.
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Abstract
backgroundHelicobacter pylori infection is associated with gastric cancer; therefore, therapies that eradicate H. pylori are crucial for its prevention. This study investigated the effects of clarithromycin (CAM)-resistance gene mutations on the success rate of H. pylori eradication and the usefulness of the Smart Gene H. pylori G (Mizuho Medy Co. Ltd., Saga, Japan) molecular diagnostic kit for H. pylori infection, which detects CAM-resistance mutations.
methodsThis study enrolled patients who underwent esophagogastroduodenoscopy, during which intragastric fluid was collected. The Smart Gene kit was used to diagnose H. pylori infection and CAM-resistance mutations, and results were compared with those of the conventional urea breath test (UBT) and real-time polymerase chain reaction (PCR) results.
resultsThe study included 253 patients. H. pylori infection was confirmed by real-time PCR in 23 (9.1%) patients, and 99 (39.1%) patients were receiving a proton pump inhibitor (PPI) or potassium-competitive acid blocker (P-CAB). The sensitivities and specificities of the Smart Gene test and UBT were 87.0% and 82.6%, as well as 99.6% and 93.0%, respectively. PPI/P-CAB use did not affect the distribution of H. pylori DNA levels measured by real-time PCR, but the UBT values were significantly lower in the medicated group than in the unmedicated group (p < 0.05). Thirteen patients underwent treatment to eradicate H. pylori, with successful eradication in 11 (84.6%). The Smart Gene test identified three patients with CAM-resistance mutations. One patient was successfully treated with a metronidazole-based regimen, whereas CAM-based eradication therapy failed in two patients.
conclusionsThe Smart Gene molecular diagnostic test using intragastric fluid was useful for patients requiring PPI/P-CAB to manage gastrointestinal symptoms. It could also confirm an H. pylori infection and CAM-resistance mutations within 1 h of testing. This diagnostic test may help reduce side effects and the emergence of resistant strains due to unnecessary eradication therapy.
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