ArticleAmerican journal of physiology. Renal physiology2026
Fibroblast histone deacetylase-1 promotes kidney interstitial fibrosis following ischemia-reperfusion injury.
Huy Nguyen, Luciano D Mendoza, Ariana S Oliver, Kaitlyn J Aldaz, Anna D Montgomery, Malgorzata Kasztan, Subhashini Bolisetty, Kelly A Hyndman
Abstract read
In one paragraphArticle in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Huy NguyenSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Luciano D MendozaSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Ariana S OliverSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Kaitlyn J AldazSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Anna D MontgomerySection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Malgorzata KasztanDivision of Hematology, Department of Medicine, Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Subhashini BolisettySection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-4650-3151 Kelly A HyndmanSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-8465-2588 Funding
Functional Significance of Ferritin Light Chain in Sepsis-associated Kidney InjuryR01DK122986 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2022 to 2025
$1.3MDeep South KUH Premier Research - Interdisciplinary Mentored Education (PRIME) Training CoreTL1DK139566 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$896kUAB-UCSD O'Brien Center for Acute Kidney Injury ResearchU54DK137307 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$872kDeep South KUH Premier Research- Interdisciplinary Mentored Education (PRIME) Networking CoreU2CDK133422 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$582kEndothelin 1 in iron handling in sickle cell diseaseR01HL173038 · UNIV OF NORTH CAROLINA CHAPEL HILL · 2025 to 2025
$574kUAB KUH KURER25DK115353 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$129kAmerican Society of Nephrology (ASN) Norman Siegel Research Grant ScholarHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL173038HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK133422HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK122986HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK126664HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R25DK115353HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) TL1DK139566HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) U54DK137307NHLBI NIH HHS R01 HL173038NIDDK NIH HHS R01 DK122986NIDDK NIH HHS R01 DK126664NIDDK NIH HHS R25 DK115353NIDDK NIH HHS TL1 DK139566NIDDK NIH HHS U2C DK133422NIDDK NIH HHS U54 DK137307
6 · The paper itselfAbstract
Interstitial fibrosis is a hallmark of chronic kidney disease, and extracellular matrix is secreted by kidney fibroblasts/pericytes that have differentiated into myofibroblasts. Class I histone deacetylases (HDACs) are highly expressed in the nucleus of kidney cells, where they regulate transcription. Class I HDAC inhibitors prevent interstitial fibrosis in preclinical models of acute kidney injury (AKI). In the warm bilateral ischemia-reperfusion injury (IRI) model, HDAC1 was the only class I HDAC with greater protein abundance following IRI, including in interstitial cells. Thus, it was hypothesized that fibroblast/myofibroblast HDAC1 activation is profibrotic.
Indexed as
Acute Kidney InjuryFibroblastsHistone Deacetylase 1KidneyReperfusion InjuryAnimalsCell ProliferationDisease Models, AnimalFemaleFibrosisMaleMiceMice, Inbred C57BLMice, KnockoutMyofibroblastsHdac1 protein, mouseHistone Deacetylase 1histone deacetylaseinjurykidneymyofibroblast
Identifiers
PMID41830491
PMCPMC13155383
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390