ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2026
From cradle to cortex: An exposome- and equity-centered perspective of neurocognitive aging and dementia risk in the era of climate change.
Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The convergence of climate change, adverse environmental exposures, and rapid population aging necessitates an equity-based paradigm shift in safeguarding brain health across the life course. Older adults, especially those in marginalized and low-resource settings, face disproportionate exposure to air pollution, toxicants, and climate-related hazards. Emerging evidence links these biophysical, social, and cultural vulnerabilities to cognitive decline and a heightened risk of developing Alzheimer's disease and related dementias (ADRDs), underscoring the need to examine cumulative exposures across the life course. Exposome-informed research integrating magnetic resonance imaging biomarkers with socioenvironmental contexts remains limited in underrepresented populations but offers opportunities to detect subclinical markers of environmental harm and illuminate mechanistic pathways of ADRDs. Thus, future studies must adopt equity-centered approaches, inclusive recruitment, and community-driven interventions to address systemic inequities and cumulative exposures. Embedding environmental justice within neuroscience will advance preventative public health policies that mitigate inequities and protect brain health during climate change. HIGHLIGHTS: Marginalized communities remain underrepresented in brain health/ Alzheimer's disease and related dementias (ADRDs) research. Toxic environmental exposures worsen inequities in brain health across the life course. Exposome-informed neuroimaging may detect early neural markers of cognitive decline. Future equity-centered exposome/neuroimaging work will inform brain health policy. Need for life course interventions to mitigate environmental risk factors of ADRDs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.