Evidence map›Paper›PMID 41830504›Full record

ReviewAmerican journal of hematology2026

Creative and Adaptive Solutions for Early Diagnosis of Sickle Cell Disease in Sub-Saharan Africa.

Luke R Smart, Catherine I Segbefia, Isaac Odame

Abstract readReview
In one paragraph

Review in American journal of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Luke R SmartDivision of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0003-4083-0060
Catherine I SegbefiaDepartment of Child Health, University of Ghana Medical School, Accra, Ghana.
Isaac OdameDivision of Haematology-Oncology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-9008-6236

Funding

Sickle Cell Anemia, Splenic Pathology, and Hydroxyurea in Sub-Saharan AfricaK23HL153763 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SMART, LUKE · 2020 to 2024
$848k
NHLBI NIH HHS K23 HL153763
6 · The paper itself

Abstract

Many of the children with sickle cell disease born in sub-Saharan Africa remain undiagnosed and untreated. Increasing capacity and infrastructure to support diagnostic and screening programs in high income countries have enabled near universal survival into adulthood. Early diagnosis and treatment are achievable goals that enjoy widespread consensus in sub-Saharan Africa but may require a variety of individualized approaches that are specific to each country. A clear understanding of the issues that influence program building is required before identifying solutions adapted to the diverse health care settings in Africa and responsive to the challenges observed during pilot programs.

Indexed as

Anemia, Sickle CellAfrica South of the SaharaEarly DiagnosisHumansMass ScreeningSub-Saharan African Peoplediagnosispoint‐of‐carescreeningsickle cell diseasesub‐Saharan Africa

Identifiers

PMID41830504
PMCPMC12988570

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.