Evidence map›Paper›PMID 41832187›Full record

ArticleNPJ science of food2026

Elucidating odorant synergy in red wine: through olfactory receptor-based profiling.

Boyong Hu, Haochen Zheng, Yanfei Shen, Hao Wang, Zhihua Liu, Haoming Lv, Lijun Han, Yinuo Ma, Heng Wang, Zuobing Xiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ science of food, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Boyong HuDepartment of Food Science & Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Haochen ZhengDepartment of Food Science & Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Yanfei ShenTechnology Center, China Tobacco Yunnan Industrial Co. Ltd, Kunming, China.
Hao WangTechnology Center, China Tobacco Yunnan Industrial Co. Ltd, Kunming, China.
Zhihua LiuTechnology Center, China Tobacco Yunnan Industrial Co. Ltd, Kunming, China.
Haoming LvDepartment of Food Science & Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Lijun HanDepartment of Food Science & Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Yinuo MaDepartment of Food Science & Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Heng WangDepartment of Food Science & Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China. wangheng0802@sjtu.edu.cn.
Zuobing XiaoDepartment of Food Science & Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China. xiaozuobing@sjtu.edu.cn.

Funding

Key Program of National Natural Science Foundation of China Grant No. 32330080Key Program of the National Natural Science Foundation of China Regional Innovation and Development Joint Fund Grant No. U24A20474Project of Yunnan Daguan Laboratory Grand No. YNDG202401CL01
6 · The paper itself

Abstract

The flavor complexity of red wine stems from diverse aroma compounds and their interactions. Key odorants 2,3,5-trimethylpyrazine (TMP) and furfuryl alcohol (FA) contribute roasted/earthy and sweet/caramel-like notes, respectively, collectively shaping the wine's sensory profile. However, the mechanism underlying their olfactory interaction remains unclear. In this study, human sensory evaluation revealed a mutual synergistic enhancement between TMP and FA. Cellular models expressing cognate receptors OR5K1 (TMP-specific) and OR2W1 (FA-responsive) were established, with intracellular cAMP detection confirming receptor-level synergy. Further molecular simulations predicted non-competitive binding mechanisms, as both odorants occupied distinct sites within their respective receptor pockets, consistent with observed non-antagonistic synergy. This work elucidates the molecular perceptual mechanism underlying key wine aroma interactions, providing a novel theoretical framework for understanding red wine flavor complexity.

Identifiers

PMID41832187
PMCPMC13133113

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.