Evidence map›Paper›PMID 41832292›Full record

ArticleScientific reports2026

CCR7 immune cell receptor expression in inflammatory breast cancer.

Jennifer H Chen, Wintana Balema, Savitri Krishnamurthy, Alison N Lawrence, Natalie W Fowlkes, Richard A Larson, Surbhi Shivhare, Caren Sanchez, Megan M Rodriguez, Jangsoon Lee and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jennifer H Chen *Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wintana Balema *MD Anderson UT Health Houston Graduate School of Biomedical Sciences, Houston, TX, USA.
Savitri KrishnamurthyDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Alison N LawrenceDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Natalie W FowlkesDepartment of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Richard A LarsonDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Surbhi ShivhareThe Morgan Welch IBC Clinic and Research Program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Caren SanchezDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Megan M RodriguezDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jangsoon LeeUniversity of Hawai'i Cancer Center, Honolulu, HI, USA.
Emilly S VillodreThe Morgan Welch IBC Clinic and Research Program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Bisrat G DebebMD Anderson UT Health Houston Graduate School of Biomedical Sciences, Houston, TX, USA.
Naoto T UenoUniversity of Hawai'i Cancer Center, Honolulu, HI, USA.
Steve Van LaereCenter for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), University of Antwerp, Universiteitsplein 1, Wilrijk, Belgium.
Francois BertucciDepartment of Medical Oncology, Institut Paoli-Calmettes, Aix-Marseille Université, Marseille, France.
Hyunwoo ChoApplied Bioinformatics Laboratories, NYU Grossman School of Medicine, New York, NY, USA.
Erik P SulmanDepartment of Radiation Oncology, NYU Langone Health, New York University, New York, NY, USA.
Bora LimThe Morgan Welch IBC Clinic and Research Program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wendy A WoodwardMD Anderson UT Health Houston Graduate School of Biomedical Sciences, Houston, TX, USA. Wwoodward@mdanderson.org.

Funding

Deciphering the Mechanism of Lymphovascular Space Invasion Using a Lymphovascularized Bioengineering Breast Stromal PlatformR01CA284102 · UNIVERSITY OF TEXAS AT AUSTIN · 2025 to 2025
$685k
NCI NIH HHS R01 CA284102NCI NIH HHS the Research and Animal Support Facility of the Cancer Center Support (Core) Grant P30 CA016672NIH HHS R01CA284102NIH HHS T32 CA 009599, P30 CA016672Susan G Komen GTDR17498270
6 · The paper itself

Abstract

Inflammatory breast cancer (IBC) is characterized by congestion of dermal lymphovascular spaces by tumor emboli. We characterized expression of CCR7, a lymphocyte homing chemokine receptor, in IBC cell lines and patient tissues. CCR7 gene expression was quantified using World IBC Consortium Database and correlated with protein expression in cell lines and IBC mastectomy samples post-neoadjuvant therapy. CCR7 expression on tissue microarray (TMA) was scored by staining pattern (complete vs. incomplete membranous), percent tumor stained, and staining intensity. CCR7 was highly expressed in IBC cell lines and a previously validated preclinical mouse model. Among 137 IBC and 252 non-IBC patient samples, CCR7 gene expression was significantly higher in IBC compared to non-IBC (p = 0.0007). Within IBC samples, gene expression was higher in HER2+ (p = 0.0002), basal (p = 0.0161), and ER- IBC patients (p = 0.010). Of the 24 IBC TMAs, almost all were CCR7 positive (23, 95.8%), with 15 (62.5%) demonstrating completely membranous expression. CCR7 is highly expressed in IBC cell lines and patient tumor samples, with preferential expression in HER2-positive and basal-like IBC subtypes. Given its high prevalence, CCR7 may serve as a potential target for antibody-based drug design in future IBC studies.

Indexed as

Inflammatory Breast NeoplasmsReceptors, CCR7AnimalsCell Line, TumorErb-b2 Receptor Tyrosine KinasesFemaleGene Expression Regulation, NeoplasticHumansMiceCCR7 protein, humanErb-b2 Receptor Tyrosine KinasesReceptors, CCR7CCL21CCR7Inflammatory breast cancerRNA seqsingle cell breast atlas

Identifiers

PMID41832292
PMCPMC13111661

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.