Evidence map›Paper›PMID 41832379›Full record

ArticleGeroScience2026

Sex dimorphism in the cardiovascular responses to d-galactose-induced accelerated aging: effects of HO-1 modulation.

Sally Wahba, Olufunto O Badmus, Andrew R Wasson, Landon D Parrow, Elshymaa A Abdel-Hakeem, Merhan Mamdouh Ragy, Hanaa Mohamad Ibrahim, David E Stec

Abstract read
PubMed Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sally WahbaDepartment of Physiology & Biophysics, Cardiovascular-Renal Research Center, Cardiorenal, and Metabolic Diseases Research Center, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Olufunto O BadmusDepartment of Physiology & Biophysics, Cardiovascular-Renal Research Center, Cardiorenal, and Metabolic Diseases Research Center, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Andrew R WassonDepartment of Physiology & Biophysics, Cardiovascular-Renal Research Center, Cardiorenal, and Metabolic Diseases Research Center, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Landon D ParrowDepartment of Physiology & Biophysics, Cardiovascular-Renal Research Center, Cardiorenal, and Metabolic Diseases Research Center, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Elshymaa A Abdel-HakeemDepartment of Medical Physiology, Faculty of Medicine, Minia University, Minia, Egypt.
Merhan Mamdouh RagyDepartment of Medical Physiology, Faculty of Medicine, Minia University, Minia, Egypt.
Hanaa Mohamad IbrahimDepartment of Medical Physiology, Faculty of Medicine, Minia University, Minia, Egypt.
David E StecDepartment of Physiology & Biophysics, Cardiovascular-Renal Research Center, Cardiorenal, and Metabolic Diseases Research Center, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA. dstec@umc.edu.ORCID http://orcid.org/0000-0001-8359-4008

Funding

Pilot Projects ProgramP30GM149404 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI John E Hall · 2023 to 2026
$6.3M
NHLBI NIH HHS 1R01HL174521-01A1NIGMS NIH HHS P30 GM149404NIGMS NIH HHS P30GM149404
6 · The paper itself

Abstract

Chronic d-galactose (d-gal) injection is an experimental model of accelerated aging in rodents. However, the cardiovascular phenotypes of this model have been poorly characterized, especially as they relate to sex differences. The goal of this study was to investigate the cardiovascular effects of chronic d-gal injection in male and female C57BL/6 mice and the impact of HO-1 induction or inhibition in this model. Forty-eight 8-week-old male and female C57BL/6 mice were divided randomly into four groups (n = 6): control, d-gal, d-gal + CoPP, and d-gal + ZnBG. Body weight, echocardiography, blood pressure measurement, Doppler ultrasound, echoMRI, micro-CT, histopathology, and protein analysis were performed. Our results show a strong sexual dimorphism in the cardiovascular effects of d-gal treatment and the effects of HO-1 induction or inhibition. Male mice were found to be more prone to systolic dysfunction and oxidative stress upon d-gal treatment and benefited more from the protective effects of HO-1 induction. Female mice were found to be protected from the cardiac effects of d-gal treatment yet were more prone to the effects of HO-1 inhibition. Our results demonstrate a sexually dimorphic response to the cardiovascular effects of d-gal treatment and alterations in HO-1.

Indexed as

Cardiac functionFibrosisHeartHypertensionOxidative stress

Identifiers

PMID41832379

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.