ArticleAIDS research and therapy2026
Near-full-length genomic characterization and phylogenetic analysis of an HIV-1 CRF02_AG/G second-generation recombinant in Ningxia, China.
Article in AIDS research and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
With the rapid evolution of global HIV-1 recombinant strains, existing diagnostic and therapeutic strategies are under threat. This study aims to conduct molecular characterization and origin tracing of a CRF02_AG-derived second-generation recombinant detected in Ningxia, China. In 2024, during genotyping screening of the pol region in HIV-1-infected individuals from Ningxia, preliminary evidence of CRF02_AG-related signals was identified in one sample. Subsequently, the near-full-length genome sequence of this strain (designated A01) was successfully obtained. Phylogenetic analysis revealed that its gag, pol, and env gene regions clustered within the A1 and G subtypes, respectively. Recombination analysis using jpHMM and Simplot software confirmed that this strain utilizes the CRF02_AG (A1/G primary recombinant) as its genomic backbone, with two G subtype fragments inserted into the env region (HXB2 sites: 6194–7137 and 7788–8532). Consequently, this strain was defined as a novel CRF02_AG/G second-generation recombinant. Bayesian phylogeographic analysis further revealed that this Ningxia strain shares close genetic relationships with CRF02_AG strains prevalent in the United Kingdom and South Korea. This study marks the first identification of an HIV-1 CRF02_AG/G second-generation recombinant in Ningxia (singular case), underscoring the importance of sustained high-resolution molecular surveillance in populations with mobility for early warning of imported and locally transmitted novel recombinant strains.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.