Evidence map›Paper›PMID 41833533›Full record

ArticleInfluenza and other respiratory viruses2026

The Development of Global Genomic Surveillance of Respiratory Syncytial Virus: Insights From 25 Project Countries, 2019-2023.

Obadiah Kenji, Fernando Motta, Thomas Williams, Nicole Wolter, Ian G Barr, Clyde Dapat, Maria Zambon, Lucy Mosscrop, Mei Shang, Sergejs Nikisins and 3 more

Erratum issuedAbstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Obadiah KenjiWorld Health Organization, Global Influenza Programme, Geneva, Switzerland.ORCID https://orcid.org/0009-0009-0677-6399
Fernando MottaLaboratório de Vírus Respiratórios Exantemáticos, Enterovírus e Emergências Virais, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.
Thomas WilliamsChild Life and Health, University of Edinburgh, Edinburgh, UK.
Nicole WolterCentre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
Ian G BarrWHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute, Melbourne, Australia.
Clyde DapatWHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute, Melbourne, Australia.
Maria ZambonVirus Reference Department, UK Health Security Agency, London, UK.
Lucy MosscropVirus Reference Department, UK Health Security Agency, London, UK.
Mei ShangWorld Health Organization, Global Influenza Programme, Geneva, Switzerland.
Sergejs NikisinsWorld Health Organization, Global Influenza Programme, Geneva, Switzerland.
Siddhivinayak HirveWorld Health Organization, Global Influenza Programme, Geneva, Switzerland.ORCID https://orcid.org/0000-0002-9651-7789
Wenqing ZhangWorld Health Organization, Global Influenza Programme, Geneva, Switzerland.
WHO RSV Surveillance Group

Funding

Bill and Melinda Gates Foundation 78084
6 · The paper itself

Abstract

backgroundFrom 2016 to 2018, the World Health Organization (WHO) initiated a global RSV surveillance pilot program in 14 countries, expanding to 25 countries from 2019 to 2023. As part of this, a sequencing program was introduced to improve the understanding of RSV global genetic diversity prior to and following the introduction of interventions such as passive immunization, vaccines, and antivirals. METHODOLOGY: All RSV sequence data submitted to GISAID by WHO project countries from January 1, 2019, to December 31, 2023, was analyzed to evaluate progress in sequencing, lineage distribution, and RSV fusion (F) protein diversity.

resultsFrom 2019 to 2023, 44,571 RSV sequences were submitted to GISAID, including 61% RSV-A and 39% RSV-B, with 34% being whole-genome sequences. WHO project countries contributed 13,280 sequences (30%), with submissions increasing from 158 in 2020 to 3716 in 2023. Median data submission time improved from 1116 days in 2020 to 206 days in 2023. The dominant lineage detected was A.D.1 (20%) for RSV-A and B.D.4.1.1 (29%) for RSV-B. The F protein sequences showed high amino acid conservation: 97% for RSV-A and 96% for RSV-B.

conclusionSubstantial progress has been made in RSV genomic sequencing capacities in WHO project countries as seen by the increased submissions and improved timeliness of sequence data. RSV exhibited co-circulating lineages (RSV-A and RSV-B) with low F protein diversity. It is important to sustain and further strengthen RSV sequencing capacities in all WHO regions as part of the ongoing WHO Global Genomic Surveillance strategy.

Indexed as

Epidemiological MonitoringGenome, ViralRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsGenetic VariationGenomicsGlobal HealthHumansPhylogenyViral Fusion ProteinsWorld Health OrganizationViral Fusion Proteinscapacity buildinggenomic sequencingRSVRSV project countries

Identifiers

PMID41833533
PMCPMC13098101

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.