Evidence map›Paper›PMID 41833535›Full record

ArticleInfluenza and other respiratory viruses2026

Incidence of RSV- and Influenza-Associated Hospitalizations With Community-Acquired Pneumonia and Other Acute Respiratory Infection Among Adults in Japan in 2022-2024: APSG-J2 Study.

Haruka Maeda, Shingo Masuda, Bhim Gopal Dhoubhadel, Yuka Fujita, Yuji Akiba, Yutaka Nishigaki, Kei Nakashima, Hiroyuki Ito, Masayuki Nogi, Yoshihito Otsuka and 15 more

Abstract readMulticenter Study
In one paragraph

Article in Influenza and other respiratory viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Haruka MaedaDepartment of Respiratory Infections, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.ORCID https://orcid.org/0000-0002-0014-2602
Shingo MasudaDepartment of Respiratory Infections, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Bhim Gopal DhoubhadelDepartment of Respiratory Infections, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Yuka FujitaDepartment of Respiratory Medicine, National Hospital Organization Asahikawa Medical Center, Asahikawa, Japan.
Yuji AkibaDepartment of Respiratory Medicine, Asahikawa-Kosei General Hospital, Asahikawa, Japan.
Yutaka NishigakiDepartment of Respiratory Medicine, Asahikawa-Kosei General Hospital, Asahikawa, Japan.
Kei NakashimaDepartment of Pulmonology, Kameda Medical Center, Kamogawa, Japan.
Hiroyuki ItoDepartment of Respiratory Infections, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Masayuki NogiDepartment of General Internal Medicine, Kameda Medical Center, Kamogawa, Japan.
Yoshihito OtsukaDepartment of Clinical Laboratory, Kameda Medical Center, Kamogawa, Japan.
Masayuki IshidaDepartment of Infectious Disease Medicine, Department of Respiratory Medicine, Chikamori Hospital, Kochi, Japan.
Eiji TakeuchiDepartment of Respiratory Medicine, National Hospital Organization Kochi Hospital, Kochi, Japan.ORCID https://orcid.org/0000-0003-1541-9747
Norichika AsohDepartment of Internal Medicine, Juzenkai Hospital, Nagasaki, Japan.
Toyomitsu SawaiDepartment of Respiratory Medicine, Nagasaki Harbor Medical Center, Nagasaki, Japan.
Koichi HayakawaDepartment of Emergency Medicine, Nagasaki Harbor Medical Center, Nagasaki, Japan.
Eileen M DunnePfizer Vaccines, Collegeville, Pennsylvania, USA.
Claudia SchwarzPfizer Vaccines, Collegeville, Pennsylvania, USA.
Bradford D GessnerPfizer Vaccines, Collegeville, Pennsylvania, USA.
Elizabeth BegierPfizer Vaccines, Collegeville, Pennsylvania, USA.
Shuhei ItoVaccine Medical Affairs, Pfizer Japan Inc., Tokyo, Japan.
Ataru IgarashiDepartment of Health Policy and Public Health, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan.
Shinobu OsanaiDivision of Respiratory Medicine and Neurology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Konosuke MorimotoDepartment of Respiratory Infections, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Koya AriyoshiDepartment of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Adult Pneumonia Study Group‐Japan 2 (APSG‐J2)

Funding

Pfizer 70109063
6 · The paper itself

Abstract

backgroundQuantifying the burden of respiratory syncytial virus (RSV) in adults is challenging compared to influenza, and data among older adults remain scarce in Japan. Country-specific evidence is essential to support RSV vaccination policy.

methodsThis prospective, multicenter study (APSG-J2) targeted hospitalized adults with community-acquired pneumonia (CAP) and other acute respiratory infections (ARI) in seven community hospitals across four catchment areas in Japan between September 2022 and August 2024. Respiratory samples were analyzed using a multiplex polymerase chain reaction (PCR) kit to detect RSV and influenza. Incidence rates of RSV- and influenza-associated hospitalizations were estimated using study data and national statistics, stratified by age and region.

resultsAmong 3047 hospitalized patients with CAP/ARI, 1499 (49.2%) underwent multiplex PCR testing. RSV and influenza were detected in 2.8% and 3.3% of tested patients, respectively. The incidences of RSV-associated CAP/ARI hospitalizations among adults aged ≥ 65 years were 29 and 36 per 100,000 person-years in the first and second years, respectively, with higher incidences among those aged ≥ 85 years (150 and 131 per 100,000 person-years). Influenza incidence increased markedly in the second year (from 11 to 71 per 100,000 person-years for adults age ≥ 65 years), possibly reflecting post-COVID-19 transmission changes.

conclusionsIn this multicenter study, we estimated the incidence of RSV- and influenza-associated hospitalizations among adults in Japan. The findings indicated that the incidence increased with age, and influenza-associated hospitalizations increased in the second year. Continued surveillance is essential to accurately assess RSV burden in the adult population.

Indexed as

Community-Acquired PneumoniaHospitalizationInfluenza, HumanRespiratory Syncytial Virus InfectionsAdultAgedAged, 80 and overFemaleHumansIncidenceJapanMaleMiddle AgedProspective StudiesRespiratory Syncytial Virus, HumanYoung Adultadultcommunity‐acquired pneumoniainfluenzaJapanrespiratory syncytial virus

Identifiers

PMID41833535
PMCPMC13098130

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.