ArticleNano letters2026
Balancing Multivalent Avidity and Receptor Availability Governs mRNA Delivery by Antibody-Functionalized Lipid Nanoparticles.
Article in Nano letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Targeted delivery of mRNA to immune cells forDrug delivery · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expanding the therapeutic scope of mRNA requires delivery systems with precise cell selectivity. Antibody-functionalized lipid nanoparticles (LNPs) enable programmable targeting, but quantitative rules linking surface avidity to delivery remain unresolved. Here, we establish a single-domain antibody (VHH)-LNP platform with controlled orientation and tunable ligand density, combined with an antigen-specific ligand binding fluorescence assay using single-particle nanoflow cytometry to quantify only functional ligands. Using this system, we show that CD8-targeted LNPs exhibit a bell-shaped dependence of delivery efficiency on ligand density, revealing an optimal avidity of ∼0.1 VHH per 100 nm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.