Evidence map›Paper›PMID 41834447›Full record

ArticleThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology2026

Inhibition of PI3K/Akt/mTOR signaling by curcumin: a novel approach to mitigate synovial fibrosis in knee osteoarthritis.

Chenglong He, Lei Shi, Licheng Zhang, Rui Jiang, Deren Liu, Taiyang Liao, Peng Wu, Jun Mao

Abstract read
In one paragraph

Article in The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chenglong HeDepartment of Orthopedics and Traumatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, P. R. China.
Lei ShiFirst College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P. R. China.
Licheng ZhangDepartment of Orthopedics and Traumatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, P. R. China.
Rui JiangDepartment of Orthopedics and Traumatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, P. R. China.
Deren LiuFirst College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P. R. China.
Taiyang LiaoKey Laboratory for Metabolic Diseases in Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P. R. China.
Peng WuDepartment of Orthopedics and Traumatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, P. R. China.ORCID https://orcid.org/0000-0002-7847-5837
Jun MaoDepartment of Orthopedics and Traumatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, P. R. China.ORCID https://orcid.org/0000-0002-1193-1957

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Curcumin (CUR) is used in treating knee osteoarthritis (KOA), but its effects on synovial fibrosis and underlying mechanisms remain unclear.

Indexed as

AutophagyCurcuminFibrosisKnee osteoarthritisPI3K/Akt/mTOR signalingSynovial

Identifiers

PMID41834447
PMCPMC13321991

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.