Article in Stroke, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
31 authors.
Sofie AbelsDepartment of Neurology (S.A., M.S., L. Tomppo, S.K., N.M.-M., L. Tulkki, J.P.), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0009-0009-4850-9918
Maximillian SihvoDepartment of Neurology (S.A., M.S., L. Tomppo, S.K., N.M.-M., L. Tulkki, J.P.), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0009-0008-0731-8296
Liisa TomppoDepartment of Neurology (S.A., M.S., L. Tomppo, S.K., N.M.-M., L. Tulkki, J.P.), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0000-0002-9369-5846
Shakar KutalDepartment of Neurology (S.A., M.S., L. Tomppo, S.K., N.M.-M., L. Tulkki, J.P.), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0009-0007-5483-435X
Nicolas Martinez-MajanderDepartment of Neurology (S.A., M.S., L. Tomppo, S.K., N.M.-M., L. Tulkki, J.P.), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0000-0001-8489-7051
Lauri TulkkiDepartment of Neurology (S.A., M.S., L. Tomppo, S.K., N.M.-M., L. Tulkki, J.P.), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0000-0003-2823-8574
Tomi SarkanenDepartment of Neurology, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, and Faculty of Medicine and Health Technology, Tampere University, Finland (T. Sarkanen).ORCID 0000-0001-8815-2807
Pekka JäkäläDepartment of Neurology, Neurocenter Neurology, Kuopio University Hospital, Finland (P.J.).ORCID 0000-0002-8410-6915
Petra RedforsDepartment of Neurology, Sahlgrenska University Hospital and Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sweden (P.R.).ORCID 0000-0001-5956-4255
Juha HuhtakangasDepartment of Neurology, Oulu University Hospital and University of Oulu, Finland (J.H.).ORCID 0000-0001-7143-519X
Pauli YlikotilaDepartment of Neurology, Turku University Hospital and University of Turku, Finland (P.Y.).ORCID 0009-0002-4126-9666
Bettina von SarnowskiDepartment of Neurology, University Medicine Greifswald, Germany (B.v.S.).ORCID 0000-0002-1458-476X
Nilufer YesilotIstanbul Faculty of Medicine, Department of Neurology, Istanbul University, Turkey (N.Y.).ORCID 0000-0002-9655-9487
Ulrike Waje-AndreassenDepartment of Neurology, Haukeland University Hospital, Bergen, Norway (U.W.-A.).ORCID 0000-0003-3240-6040
Ana Catarina FonsecaFaculty of Medicine, Department of Neurology, Hospital de Santa Maria, University of Lisbon, Portugal (A.C.F.).ORCID 0000-0001-6913-5526
Patricia Martinez SanchezDepartment of Neurology, Torrecardenas University Hospital, University of Almeríaa, Spain (P.M.S.).ORCID 0000-0003-1945-4435
Janika KõrvDepartment of Neurology and Neurosurgery, University of Tartu, Estonia (J.K.).ORCID 0000-0002-6074-0727
Phillip FerdinandNeurosciences, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, United Kingdom (P.F.).
Kristina RyliskieneFaculty of Medicine, Center of Neurology, Vilnius University, Lithuania (K.R.).ORCID 0000-0001-9596-1733
Alessandro PezziniDepartment of Medicine and Surgery, Department of Emergency, University of Parma and Stroke Care Program, Parma University Hospital, Italy (A.P.).ORCID 0000-0001-8629-3315
Radim LicenikNorth West Anglia NHS Foundation Trust, Acute Stroke Centre, Peterborough, United Kingdom (R.L.).ORCID 0000-0002-9145-4598
Marialuisa ZeddeNeurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS Reggio EmiliaSanitaria Locale-IRCCS Reggio Emilia, Italy (M.Z.).ORCID 0000-0001-7530-818X
Mika LehtoDepartment of Cardiology, Heart and Lung Center (M.L., J.S.), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0000-0002-8691-5142
Juha SinisaloDepartment of Cardiology, Heart and Lung Center (M.L., J.S.), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0000-0002-0169-5137
Eva GerdtsDepartment of Clinical Science, Center for Research on Cardiac Disease in Women, University of Bergen, Norway (E.G.).ORCID 0000-0003-4109-2311
Hugo Ten CateDepartment of Internal Medicine, Maastricht University Medical Center and CARIM School for Cardiovascular Diseases, the Netherlands (H.T.C.).ORCID 0000-0001-7796-4463
Tuukka A HelinDepartment of Clinical Chemistry, HUS Diagnostic Center (T.A.H., L.J.-K.), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0000-0002-5273-8088
Lotta Joutsi-KorhonenDepartment of Clinical Chemistry, HUS Diagnostic Center (T.A.H., L.J.-K.), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0000-0002-7355-2354
Tímea SzántóUnit of Coagulation Disorders, Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center and University of Helsinki, Finland (T. Szántó).ORCID 0000-0001-7006-6564
Frank-Erik de LeeuwRadboud Institute for Medical Research and Innovation, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience (F.-E.d.L.), Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0003-2221-3026
Jukka PutaalaDepartment of Neurology (S.A., M.S., L. Tomppo, S.K., N.M.-M., L. Tulkki, J.P.), Helsinki University Hospital and University of Helsinki, Finland.ORCID 0000-0002-6630-6104
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
backgroundThe incidence of cryptogenic ischemic stroke (CIS) in young adults is increasing, particularly among those without traditional vascular risk factors. Thrombophilia may contribute to CIS pathogenesis, yet guidelines differ on the relevance of screening. We investigated the sex-specific prevalence of routinely applied thrombophilia screening in young-onset CIS and its association with clinical characteristics and standard laboratory results.
methodsWe included young patients with CIS aged 18 to 49 years from the SECRETO study (Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Triggers, Causes, and Outcome). Routinely used thrombophilia panels obtained at admission and repeated testing within 1 year of stroke were analyzed. Ten thrombophilia markers were assessed and categorized according to the grade of deviation into lowest, low, and high thrombosis risks. Factors associated with any deviation in thrombophilia markers were investigated with multivariable logistic regression.
resultsOf 598 initially enrolled patients with CIS, 556 undergoing baseline thrombophilia testing were analyzed (median age, 41.0 [interquartile range, 34.1-45.8] years; male:female ratio 1.2:1). Of these, 120 (21.6%) and 36 (6.5%) were retested by 3 and 12 months, respectively. At baseline, any thrombophilia abnormality was observed in 206 patients (37.1%; men, 38.2%; women, 35.7%). High-risk thrombophilia was identified in 29 patients (5.2%) at baseline, in 13 retested patients (11.1%) at 3 months, and in 5 retested patients (13.9%) at 12 months. Overall, 45 patients (8.1%) had persistent thrombophilia abnormalities (men, 7.9%; women, 8.3%). Physical inactivity, a history of venous thromboembolism, low HDL (high-density lipoprotein)-cholesterol, and low hemoglobin were associated with any deviation in the thrombophilia markers. Anticoagulation was initiated in 50.0% of patients with abnormal baseline thrombophilia versus 35.7% without (
conclusionsOver a third of young adults with CIS had thrombophilia deviations at admission although high-risk thrombophilia results remained rare. Screening may be considered in young patients with CIS with a history of venous thromboembolism, physical inactivity, and low hemoglobin or HDL-cholesterol.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.