ArticleFrontiers in reproductive health2026
Precautions for polygenic embryo selection: prohibition or cautious use.
Article in Frontiers in reproductive health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Polygenic scores derived from inborn genetic variation are expected to predict individuals' complex traits. Preimplantation genetic testing for polygenic scores is already offered to help parents select embryos deemed "healthy" and/or "intelligent", raising ethical concerns. This paper analyzes the implications of polygenic embryo selection and proposes policy responses. Although substantial clinical uncertainty persists, use is likely to expand because parents seek desirable traits. Yet resulting offspring may not meet such expectations due to environmental influences (including parental behavior), offspring's genomes, and their autonomy. These practices risk generating socio-ethical harms, including false expectations, child objectification, and trait-based stigma. Professional societies and policymakers should therefore warn parents about these risks, and consider prohibiting polygenic embryo selection, although they might eventually permit cautious use for serious late-onset diseases.
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