Evidence map›Paper›PMID 41834969›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2026

[Neutrophil-derived Microvesicles Regulate DNA Methylation of the

Zhijie Zhao, Maodan Tang, Yan Liang, Tianjian Zhang, Qiuyu Ren, Qing Cheng, Yu Xiong, Ke Ma, Dong Zhan

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhijie Zhao（ 650500）School of Basic Medicine, Kunming Medical University, Kunming 650500, China.ORCID 0009-0004-5258-3321
Maodan Tang（ 650500）School of Basic Medicine, Kunming Medical University, Kunming 650500, China.
Yan Liang（ 650500）School of Basic Medicine, Kunming Medical University, Kunming 650500, China.
Tianjian Zhang（ 650500）School of Basic Medicine, Kunming Medical University, Kunming 650500, China.
Qiuyu Ren（ 650500）School of Basic Medicine, Kunming Medical University, Kunming 650500, China.
Qing Cheng（ 650500）School of Basic Medicine, Kunming Medical University, Kunming 650500, China.
Yu Xiong（ 650500）School of Basic Medicine, Kunming Medical University, Kunming 650500, China.
Ke Ma（ 650500）School of Basic Medicine, Kunming Medical University, Kunming 650500, China.
Dong Zhan（ 650500）School of Basic Medicine, Kunming Medical University, Kunming 650500, China.ORCID 0000-0001-9540-3715

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate how neutrophil-derived microvesicles (NDMV) promote Methods: Neutrophils were isolated from the peripheral blood of healthy volunteers and stimulated with tumor necrosis factor α (TNFα) to produce NDMV. Primary FLS were cultured to the fourth passage for use. MTT assays determined the optimal NDMV treatment ratios and durations for FLS. Experiments groups included control, TNFα, NDMV, and TNFα + NDMV. Combined bisulfite restriction analysis (COBRA) assessed global Results: No significant cytotoxicity was observed at NDMV∶FLS ratios ≤ 100∶1 ( Conclusion: NDMV enhances

Indexed as

Cell-Derived MicroparticlesDNA MethylationFibroblastsLong Interspersed Nucleotide ElementsNeutrophilsSynoviocytesCells, CulturedDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesHumansTumor Necrosis Factor-alphaDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNMT1 protein, humanTumor Necrosis Factor-alphaDNA methyltransferasesFibroblast-like synoviocytesNeutrophil-derived microvesiclesRheumatoid arthritis

Identifiers

PMID41834969
PMCPMC12979991

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.