ArticleFrontiers in neurology
Associations of modified triglyceride-glucose indices with risks of dementia subtypes and brain structure: a prospective cohort study.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- TyG index and mild cognitive impairment and dementia: a review of current evidence.Frontiers in aging neuroscience · 2026Review
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Authors and funding
5 authors.
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Abstract
Background: The associations of modified triglyceride-glucose (TyG) indices with risks of dementia subtypes and brain structural changes remain unclear. This study prospectively examines whether modified TyG indices, including TyG with body mass index (TyG-BMI) and TyG with waist circumference (TyG-WC), are associated with the risks of Alzheimer's disease (AD) and vascular dementia (VaD) and with structural brain alterations. Materials and methods: This study analyzed 356,454 dementia-free participants from the UK Biobank. Multivariable-adjusted Cox proportional hazards models were used to estimate hazard ratios (HRs) for incident AD and VaD. Restricted cubic spline (RCS) analyses assessed nonlinear relationships. Linear regression models evaluated associations between modified TyG indices and brain structures, including hippocampal volume and white matter hyperintensity (WMH) volume. Subgroup analyses and sensitivity analyses were performed to test robustness. Results: During follow-up, 2,594 AD and 1,386 VaD cases were identified. In fully adjusted Cox models, both TyG-BMI and TyG-WC showed clear dose-response patterns with dementia risk. Using Q5 as the reference, participants in the lowest sextile (Q1) had a 47% higher risk of AD for TyG-BMI (HR = 1.47, FDR-adjusted Conclusion: Modified TyG indices show nonlinear, differential associations with AD and VaD risks, and are linked to structural brain alterations. These findings highlight the importance of metabolic health in dementia prevention and brain aging.
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