Evidence map›Paper›PMID 41835333›Full record

ArticleFrontiers in immunology2025

Hepatic zinc deficiency dampens the acute phase response in patients with alcohol-associated hepatitis.

Scott A Read, Mehdi Ramezani-Moghadam, Brian S Gloss, Romario Nguyen, Benjamin Woodham, Vincent Lam, Lawrence Yuen, Jimin Yoon, Liang Qiao, Thomas Tu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Scott A ReadBlacktown Clinical School, Western Sydney University, Blacktown, NSW, Australia.
Mehdi Ramezani-MoghadamBlacktown Clinical School, Western Sydney University, Blacktown, NSW, Australia.
Brian S GlossWestmead Research Hub, Westmead Institute for Medical Research, Westmead, NSW, Australia.
Romario NguyenStorr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital, Westmead, NSW, Australia.
Benjamin WoodhamBlacktown Hospital, Western Sydney Local Health District (WSLHD), Blacktown, NSW, Australia.
Vincent LamWestmead Hospital, Western Sydney Local Health District, Westmead, NSW, Australia.
Lawrence YuenWestmead Hospital, Western Sydney Local Health District, Westmead, NSW, Australia.
Jimin YoonDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, United States.
Liang QiaoStorr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital, Westmead, NSW, Australia.
Thomas TuStorr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital, Westmead, NSW, Australia.
Jacob GeorgeStorr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital, Westmead, NSW, Australia.
Matthew D ShouldersDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, United States.
Golo AhlenstielBlacktown Clinical School, Western Sydney University, Blacktown, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Zinc deficiency affects ~17% of the population globally, contributing to deficits in growth, metabolism and immunity. Serum zinc is greatly reduced in alcohol-associated hepatitis, driven by hepatic dysfunction and poor zinc retention. While zinc is an essential micronutrient with many beneficial anti-inflammatory and anti-oxidant properties, its role in the progression of alcohol-related liver disease (ALD) remains uncertain. Methods: To identify broad transcriptomic responses to zinc, 11 publicly available datasets were examined to generate a transcriptomic zinc signature. Zinc signature genes were validated in vitro using primary immune cell and hepatocyte models supplemented with zinc or depleted of zinc using a S100A12 conjugated resin. The role of zinc deficiency in alcohol-associated hepatitis was examined bioinformatically, using large publicly available datasets, and confirmed Results: A nine gene zinc signature consisting primarily of metallothonein genes identified hepatic zinc deficiency among ALD patients that was associated with a down-regulation of the acute phase response pathway (e.g., Discussion: Together, these data suggest that hepatic zinc stores among patients with alcohol-associated hepatitis are reduced, resulting in deficient acute-phase responses. Increasing hepatic zinc stores via supplementation and dietary modulation may improve acute responses to infection, and thus, long term outcomes in this patient group.

Indexed as

Acute-Phase ReactionHepatitis, AlcoholicLiverZincAnimalsGene Expression ProfilingHepatocytesHumansMacrophagesTranscriptomeZincacute phase responsealcohol-associated hepatitisalcohol-related liver diseasemetallothioneinzinczinc deficiencyzinc signature

Identifiers

PMID41835333
PMCPMC12979129

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.