Evidence map›Paper›PMID 41835401›Full record

ArticlebioRxiv : the preprint server for biology2026

Clathrin is an Intrinsic Driver of Membrane Fission.

Nicoletta Bouzos, Samuel L Foley, Ariadni Potamianos, Ciara O Jacobs, Margaret E Johnson, Wade F Zeno

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nicoletta BouzosMork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA 90089, United States.
Samuel L FoleyT. C. Jenkins Department of Biophysics, The Johns Hopkins University, 3400 N. Charles St., Baltimore, Maryland 21218, USA.
Ariadni PotamianosMork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA 90089, United States.
Ciara O JacobsMork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA 90089, United States.
Margaret E JohnsonT. C. Jenkins Department of Biophysics, The Johns Hopkins University, 3400 N. Charles St., Baltimore, Maryland 21218, USA.ORCID 0000-0001-9881-291X
Wade F ZenoMork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA 90089, United States.ORCID 0000-0002-2341-8923

Funding

Mechanisms of Protein Self-Assembly Coupled to Membrane Mechanics in the Cell.R35GM133644 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI JOHNSON, MARGARET ELLEN · 2019 to 2023
$2.0M
Dynamic Interactions between Intrinsically Disordered Proteins and Curved Membrane SurfacesR35GM147333 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Wade F Zeno · 2022 to 2026
$2.0M
NIGMS NIH HHS R35 GM133644NIGMS NIH HHS R35 GM147333
6 · The paper itself

Abstract

The extent to which clathrin directly drives membrane curvature during endocytosis has remained a central, longstanding question in the field of endocytosis. Using a synthetic reconstitution system that recruits clathrin to lipid membranes independent of adaptor proteins, we demonstrate that clathrin alone can induce membrane fission and that its capacity to do so is governed by the mechanical properties of the lattice. Counterintuitively, conditions that strengthen lattice assembly suppress fission, whereas weakened assembly enhances fission despite reduced membrane association. Meso-scale Brownian dynamics reveal that assembly dependent changes in triskelion geometry and lattice stiffness dictate curvature generation, corroborating these findings. These principles are further extended when clathrin is recruited by adaptor proteins amphiphyin1 or epsin1, with clathrin either enhancing or restricting fission based on adaptor specific tuning of lattice mechanics. Lastly, perturbations to clathrin assembly in live cells shift endocytic pit dynamics, with Ca

Identifiers

PMID41835401
PMCPMC12980386

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.