ArticleFrontiers in public health2026
Negative influence of age and low baseline CD4 on T helper cell recovery among HIV-infected individuals with fixed-dose combination of tenofovir disoproxil, lamivudine and dolutegravir.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: A discordant immune response (DIR) refers to inadequate CD4 Methods: This study evaluated DIR in HIV-positive patients receiving a first-line regimen of tenofovir disoproxil fumarate, lamivudine and dolutegravir (TLD) at the ART Centre, Saveetha Medical College and Hospital, Chennai, India. DIR was defined as virological suppression to <150 copies/mL and a CD4 Results: Out of the 112 patients screened, 40 were enrolled in the study. Of the 40 participants 55% (22/40) showed DIR, with equal proportions in DIR350 (27.5%) and DIR500 (27.5%), while 45% (18/40) achieved immune reconstitution. By using ordinal regression analysis, the study found that the baseline CD4 counts were significantly associated with DIR. Univariate analysis indicated that age, baseline CD4 and treatment duration were significantly associated with CD4 recovery. Conclusion: The study highlights that, despite viral suppression with TLD, a substantial proportion of patients fail to achieve adequate immune restoration. Lower baseline CD4 was observed to be a key predictor of DIR. These findings underscore the need for early ART initiation, targeted adherence support, and counselling to optimize outcomes and progress toward the UNAIDS 95 target.
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