ArticleACS omega2026
TPGS and CS-Surface-Modified DPPC Liposomes Coloaded with Docetaxel and 5‑Fluorouracil: A Potential Avenue for Enhanced Colorectal Cancer Therapy.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Colorectal cancer (CRC) continues to be a foremost human health concern globally, with chemotherapy being the cornerstone of the therapy. However, conventional chemotherapy is often hampered by nonspecific targeting, limited efficiency, drug resistance, and undesirable adverse effects. 5-Fluorouracil (5-FU), the primary agent for CRC treatment, has a short duration of action and causes systemic toxicity. Docetaxel (DTX), another chemotherapeutic agent, has shown potential in CRC therapy, but its use is also hindered by poor targeting and resistance. Therefore, advanced drug delivery carriers can enhance their therapeutic efficacy. This combination offers a synergistic effect by targeting multiple pathways concurrently. This study aimed to design and assess dipalmitoylphosphatidylcholine (DPPC) liposomes (LPs) coloaded with DTX and 5-FU, surface-modified with d-α-tocopheryl poly-(ethylene glycol) succinate (TPGS-LPs) and chitosan (CS-LPs), as a dual-drug delivery for CRC therapy. Various LPs based on TPGS and CS, containing 5-FU and DTX, were successfully prepared and characterized by dynamic light scattering (DLS), and their entrapment efficiencies (EE%) were determined. The optimized formulations, DTX-TPGS-LPs, 5-FU-TPGS-LPs, and DTX/5-FU-TPGS-LPs, were subjected to
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Registered trials
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