ArticleClinical, cosmetic and investigational dermatology2026
Clinical Insights into the Pathogenesis and Treatment Strategies of Acanthosis Nigricans: A Bibliometric Study of Current Trends and Future Directions.
Article in Clinical, cosmetic and investigational dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
Background: Acanthosis nigricans (AN) is a recognized cutaneous marker of insulin resistance and metabolic syndrome. Despite its clinical significance and associations with various comorbidities, a comprehensive, quantitative overview of the research landscape is lacking. Objective: This study aimed to conduct a bibliometric analysis to map the global research output, identify key themes and trends, and elucidate the comorbidity network and potential therapeutic strategies for AN. Methods: We performed a bibliometric analysis using publications retrieved from the Web of Science Core Collection (until May 13, 2024). Data from 2098 publications were analyzed using VOSviewer for co-authorship and keyword co-occurrence networks, CiteSpace for temporal trend and burst detection, and the R package bibliometrix for thematic mapping and publication metrics. Results: Analysis revealed that original articles constituted 85.7% of the literature. Research output has accelerated markedly since 2010. Four core research clusters were identified: obesity/metabolic, hormonal, genetic, and malignancy-related. Key comorbidities with strong bibliometric linkages included psoriasis, hidradenitis suppurativa (HS), and acne, centered on shared mechanisms of insulin resistance and inflammation. The analysis highlighted emerging therapeutic directions, particularly the potential of GLP-1 receptor agonists (eg, semaglutide) due to their dual metabolic and anti-inflammatory (eg, TNF-α, IL-17 inhibition) effects, and the complex role of biologics targeting Th1/Th17 pathways. Conclusion: This first bibliometric study of AN delineates its evolving research architecture, confirming its position at the intersection of dermatology, endocrinology, and immunology. The findings underscore shared pathophysiological pathways with several inflammatory skin diseases and point to novel, mechanism-based therapeutic strategies. Future research should prioritize clinical trials to validate these targeted interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.