ArticleFrontiers in pharmacology2026
Ketoprofen-loaded quatsomes as a smart repurposed antifungal therapy for vaginal infections: formulation, characterization, and microbiological evaluation.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Quaternary Ammonium-Functionalized Chitosan as a Next-Generation Antifungal Platform: Chemistry, Mechanisms, and Therapeutic Applications.Marine drugs · 2026Review
- Advanced modafinil-loaded transethosomes for brain targeting: development, ex-vivo permeation and radio-distribution evaluations.Drug delivery and translational research · 2026Article
- Harnessing Hybrid Niosomes for Improved Oral Bioavailability of an Anticoagulant: Design, Optimization and In-Vivo Pharmacokinetics and Pharmacodynamics Evaluations.AAPS PharmSciTech · 2026Article
- Innovative hyaluronic acid-decorated quatsomes for enhanced renal targeting: design, optimization andJournal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2026Article
- An integrative neuropharmacological review of Huntington's disease challenges and the role of novel formulations in addressing pharmacological‒pharmaceutical limitations.Frontiers in pharmacology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
Introduction: Vulvovaginal candidiasis (VVC) is one of the most common fungal infections requiring more effective and patient-friendly therapies. This study introduces repurposed Ketoprofen (KPN) Quatsomes (QS) as a novel nano-platform for localized antifungal treatment. Methods: KPN-QS were prepared using quaternary ammonium surfactants and cholesterol via probe sonication and optimized through a 3 Results: The optimized QS exhibited spherical nano-sized vesicles (113.7 nm) with high entrapment efficiency (96.8%) and strong positive zeta potential (72.5 mV), ensuring stability and enhanced mucosal adhesion. TEM confirmed the spherical morphology, and Conclusion: Collectively, repurposed KPN-QS constitute a stable, biocompatible nanocarrier for targeted vaginal delivery, demonstrating superior antifungal activity and therapeutic potential in VVC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.