ArticleChemistry of materials : a publication of the American Chemical Society2026
Cell-Laden Supramolecular and Covalent Polymer Hydrogels for High-Shear Delivery: A Design of Experiments Approach.
Article in Chemistry of materials : a publication of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Effective design of cell-delivery scaffolds is of key importance for regenerative medicine technologies to meet their full potential, especially when considering cell delivery to wounds of complex architecture or directly into the biological environment. Few studies, however, focus on a systematic approach to understanding the cell, polymer scaffold, and final biomaterial properties of this composite material. In this work, we report on the systematic analysis of a supramolecular hydrogel composed of ionically cross-linked peptide amphiphile (PA) nanofibers, optimized for high-shear delivery of therapeutic cells, and compare the performance of this biomaterial to a covalent polymer hydrogel of ionically cross-linked alginate. Using a full factorial design of experiments (DoE), we investigated the interplay between polymer concentration and cell loading to determine the impact on mechanical properties, structural integrity, substrate adhesion, and sprayability of the hydrogel. The shear-thinning and thixotropic nature of the supramolecular hydrogels enabled effective deposition through a spray nozzle, not possible with the alginate hydrogel, while preserving cell viability and hydrogel mechanical properties. The supramolecular backbone of the PA nanofibers enabled remarkable mechanical resilience and full recovery post-spray, even at cell loadings as high as 2 million cells/mL, while significant loss of gel integrity was observed with the alginate hydrogel at equivalent cell loadings. Our findings establish a robust structure-property relationship framework for the formulation of cell-laden supramolecular hydrogels capable of high-shear delivery, highlighting their potential as customizable platforms for regenerative medicine, advanced wound care, and 3D printing applications.
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