ArticleFrontiers in oncology2026
Microtransplantation improves the outcome of older patients with newly diagnosed acute myeloid leukemia: a single-center study with long-term follow-up.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Microtransplantation (MST) combines chemotherapy with infusion of HLA-mismatched granulocyte colony-stimulating factor-mobilized peripheral blood stem cells (G-PBSCs) without graft-versus-host disease (GVHD) prophylaxis, offering a potential therapeutic alternative for older acute myeloid leukemia (AML) patients. Methods: In this single-center study, 29 patients aged ≥60 years with newly diagnosed non-acute promyelocytic leukemia (AML) received MST between April 2008 and June 2021. Patients were stratified into two age cohorts: 60-70 years ( Results: The median follow-up was 148.5 months (range 52.96-219.12). The CR rate was 86.2% (25/29), with no significant difference between age groups (90.0% vs. 66.7%, Conclusion: MST is an effective and tolerable treatment for older AML patients, particularly those aged 60-70 years and those receiving more than three treatment courses. These results support MST as a viable alternative for older patients ineligible for intensive transplantation.
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