ArticleChem2024
From G protein-coupled receptors to solute carriers - mass spectrometry informs dynamics, function and regulation.
Article in Chem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Recent Advances in Mass Spectrometry-Based Bottom-Up Proteomics.Analytical chemistry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capturing the dynamics of G protein-coupled receptors (GPCRs) as they transduce extracellular signals into key physiological processes remains one of the most challenging research areas over the last two decades. Meanwhile more recent attention has turned to the action of solute carriers (SLCs) that comprise both facilitative transporters and secondary active transporters. Since GPCRs and SLCs play critical roles in health and disease, and thereby serve as major targets for drug discovery, much effort has focused on capturing their various conformational states using conventional structural biology techniques. Here we consider roles that mass spectrometry-based approaches play, particularly with respect to uncovering the impact of phosphorylation, defining ligands and revealing the action of lipids in modulating interactions, transport, and conformational dynamics.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.