Evidence map›Paper›PMID 41836435›Full record

ReviewFrontiers in immunology2026

Heme oxygenase-1 and malaria pathogenesis.

Theophilus Wakai, Shalom Chinedu, Israel Afolabi

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Targeting elongation factor 2 inFrontiers in insect science · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Theophilus WakaiMalaria Research Unit, Covenant Applied Informatics and Communication-Africa Centre of Excellence (CApIC-ACE), Ota, Nigeria.
Shalom ChineduDepartment of Biochemistry, College of Science and Technology, Covenant University, Ota, Nigeria.
Israel AfolabiDepartment of Biochemistry, College of Science and Technology, Covenant University, Ota, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria is a life-threatening parasitic disease and remains a major cause of morbidity and mortality worldwide. The clinical course of malaria ranges from uncomplicated infection to severe disease, driven by extensive hemolysis, inflammation, and oxidative stress. Heme oxygenase-1 (HO-1), an inducible enzyme involved in heme degradation, has been demonstrated to play a crucial role in the host's response to

Indexed as

Heme Oxygenase-1MalariaAnimalsBiomarkersHost-Parasite InteractionsHumansPlasmodiumBiomarkersHeme Oxygenase-1biomarkerheme oxygenase-1malariaoxidative stresspathogenesis

Identifiers

PMID41836435
PMCPMC12982344

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.