ReviewJournal of orthopaedic translation2026
The brain-gut-joint axis in arthritis: crosstalk, treatment, and future perspectives.
Review in Journal of orthopaedic translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arthritis is an inflammatory disease that affects the joints and often leads to disability and dysfunction, significantly impacting human health. The brain-gut-joint axis is a complex regulatory network that involves the joints and has a profound influence on the development of arthritic diseases by regulating the microenvironment at joint sites. There is a lack of comprehensive reviews on the interplay of the brain-gut-joint axis and its impact on the onset and progression of arthritis, as well as on the innovative therapies for treating the condition. Consequently, the purpose of this review is to uncover the communication between the brain, gut, and joints and to explore their influence on the pathogenesis and progression of arthritis. These interactions can affect the joint microenvironment by modulating various physiological systems, including the immune, metabolic, and nervous systems. Furthermore, therapeutic strategies aimed at improving arthritis by regulating the gut microbiota and maintaining brain health are discussed. This review offers a novel perspective on the development, diagnosis, and treatment of arthritic diseases, with significant implications for enhancing patient well-being. The translational potential of this article: This paper reviews the interactions within the brain-gut-joint axis and its pivotal role in the pathogenesis and progression of arthritis (involving immune, endocrine, neural, and metabolic pathways). It also discusses emerging therapeutic approaches for arthritis based on maintaining the balance of the brain-gut-joint axis, along with future research prospects. These insights will provide direction for exploring emerging therapies for arthritis while further refining clinical strategies for managing the condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.