Evidence map›Paper›PMID 41836585›Full record

ArticleJournal of orthopaedic translation2026

Plasma-derived exosomes from obese knee osteoarthritis aggravate synovitis by promoting cellular senescence of synovial fibroblasts.

Bin Zhang, Hailin Wang, Wanwan Qi, Song Li, Lun Tao, Xiuqin Peng, Yangli Xie, Liang Kuang, Peiyu Teng, Xiaoqi Zhang and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Bin ZhangDepartment of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair, Laboratory for Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Hailin WangDepartment of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair, Laboratory for Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Wanwan QiDepartment of Thyroid and Breast Surgery, Bishan Hospital of Chongqing Medical University, Bishan Hospital of Chongqing, Chongqing, China.
Song LiDepartment of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair, Laboratory for Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Lun TaoDepartment of Orthopaedics, Wushan County People's Hospital, Chongqing, China.
Xiuqin PengDepartment of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair, Laboratory for Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Yangli XieDepartment of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair, Laboratory for Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Liang KuangDepartment of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair, Laboratory for Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Peiyu TengDepartment of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair, Laboratory for Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Xiaoqi ZhangState Key Laboratory of Trauma, Burns and Combined Injury, Department of Rehabilitation Medicine, Daping Hospital, Army Medical University, Chongqing, China.
Xiangdong LiuDepartment of Orthopaedics, Daping Hospital, Army Medical University, Chongqing, China.
Daibo FengState Key Laboratory of Trauma, Burns and Combined Injury, Department of Rehabilitation Medicine, Daping Hospital, Army Medical University, Chongqing, China.
Yunquan GongState Key Laboratory of Trauma, Burns and Combined Injury, Department of Rehabilitation Medicine, Daping Hospital, Army Medical University, Chongqing, China.
Wei XiangState Key Laboratory of Trauma, Burns and Combined Injury, Department of Rehabilitation Medicine, Daping Hospital, Army Medical University, Chongqing, China.
Tongyi ZhangState Key Laboratory of Trauma, Burns and Combined Injury, Department of Rehabilitation Medicine, Daping Hospital, Army Medical University, Chongqing, China.
Bo HuangState Key Laboratory of Trauma, Burns and Combined Injury, Department of Rehabilitation Medicine, Daping Hospital, Army Medical University, Chongqing, China.
Siru ZhouState Key Laboratory of Trauma, Burns and Combined Injury, Medical Center of Trauma and War Injury, Daping Hospital, Army Medical University of PLA, Chongqing, China.
Lin ChenDepartment of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair, Laboratory for Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Yan XiongDepartment of Orthopaedics, Daping Hospital, Army Medical University, Chongqing, China.
Zhenhong NiState Key Laboratory of Trauma, Burns and Combined Injury, Department of Rehabilitation Medicine, Daping Hospital, Army Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: As the most important risk factor for knee osteoarthritis (OA), obesity is closely associated with the clinical symptoms of OA. This study aims to systematically analyze the exosomal RNAs signatures in the plasma of knee OA patients with different body mass index (BMI) and to investigate their pathological roles and potential mechanisms in synovitis. Methods: The clinical information of 101 patients with knee OA was recorded and the correlation with BMI was analyzed. The plasma-derived exosomes were extracted from non-obese and obese patients with OA (EXOs Results: There was a positive relationship between BMI and WOMAC score, but a negative relationship between BMI and HSS score in knee OA patients. The RNAs sequencing identified 143 miRNAs (72 down-regulated and 71 up-regulated), 29 lncRNAs (15 up-regulated and 14 down-regulated), and 334 mRNAs (189 up-regulated and 145 down-regulated) that were significantly differentially expressed in plasma-derived exosomes between obese and non-obese OA patients. However, there were no differentially expressed circRNAs between two groups. Furthermore, KEGG and GO analysis of miRNAs showed that several cellular senescence-related pathways were significantly enriched in EXOs Conclusion: Plasma EXOs The translational potential of this article: This article provides the whole profiles of differentially expressed plasma-derived exosomal RNAs between non-obese and obese OA patients, which are beneficial for the future research in this field. The data suggest that plasma-derived exosomes in obese OA patients exacerbate synovitis through augmentation of synovial fibroblast senescence, thereby positioning molecular mediators in plasma-derived exosomes, such as miR-192-5p, as promising therapeutic targets for obesity-associated OA patients.

Indexed as

Cellular senescenceExosomeFibroblastObesityOsteoarthritisSynovitis

Identifiers

PMID41836585
PMCPMC12988516

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.