ReviewInternational journal of nanomedicine2026
From Barrier to Gateway: Nanomaterials Reshaping the Tumor Microenvironment for Therapy.
Review in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tumor microenvironment constitutes the external condition that supports the survival and development of tumor cells. It promotes tumor cell proliferation and survival by secreting various cytokines and the provision of nutritional support, thereby driving tumor advancement. However, its structural density and complex composition pose significant barriers to drug delivery and therapeutic intervention, necessitating the development of advanced techniques for effective penetration. In recent years, nanotechnology, characterized by its distinctive physicochemical properties and excellent targeting and regulatory capabilities, has shown tremendous potential in overcoming the tumor microenvironment barriers, garnering significant research interest. This paper systematically summarizes the formation mechanisms of various TME subtypes, including immunosuppressive, metabolic, acidic, hypoxic, stromal, mechanical, microbial, inflammatory, and neural TME. It analyzes the principal challenges faced by nanomaterials in regulating these microenvironments, focuses on research strategies and application prospects of nanomaterials across different subtype microenvironments, and proposes novel directions for future investigation. The objective is to facilitate breakthroughs in the translational application of nanomaterials from mechanistic innovation to clinical practice.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.