Evidence map›Paper›PMID 41836733›Full record

ArticleCurrent problems in cancer. Case reports2026

Breast-implant associated unicentric castleman disease: a case report.

Saishravan Shyamsundar, Mateo Sarmiento Bustamante, Larissa Borys, Megan S Lim, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Gordan Srkalovic, Frits van Rhee and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current problems in cancer. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Saishravan ShyamsundarCenter for Cytokine Storm Treatment & Laboratory, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mateo Sarmiento BustamanteCenter for Cytokine Storm Treatment & Laboratory, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Larissa BorysCenter for Cytokine Storm Treatment & Laboratory, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Megan S LimDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
Adam BaggDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mary Jo LechowiczDepartment of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA, USA.
Daisy AlapatDepartment of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Amy ChadburnDivision of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Gordan SrkalovicUniversity of Michigan Health-Sparrow Herbert-Herman Cancer Center, Lansing, MI, USA.
Frits van RheeMyeloma Center, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Bridget AustinCenter for Cytokine Storm Treatment & Laboratory, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Joshua D BrandstadterCenter for Cytokine Storm Treatment & Laboratory, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
David C FajgenbaumCenter for Cytokine Storm Treatment & Laboratory, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
mTOR as a Central Regulator of iMCD Pathogenesis and Novel Therapeutic TargetR01HL141408 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Taku Kambayashi · 2018 to 2026
$6.1M
FDA HHS R01 FD007632NCI NIH HHS P30 CA008748NHLBI NIH HHS R01 HL141408
6 · The paper itself

Abstract

ALK-negative anaplastic large cell lymphoma is a well-established hematologic complication of prosthetic breast implantation, but other rare conditions should also be considered. We report a case of a 36-year-old female with bilateral retropectoral breast implants since age 20 who presented with fatigue, lower extremity edema, fevers, and a slowly growing left breast mass. Ultrasound of the left breast revealed a 6 × 6 cm left upper quadrant mass. Surgical excision identified pathologic features consistent with hyaline-vascular unicentric Castleman disease (UCD). This is the first case of breast-implant associated UCD, expanding the differential diagnosis for masses associated with prosthetic breast implantation.

Indexed as

BIA-ALCLBreast implantsCastleman diseaseUnicentric

Identifiers

PMID41836733
PMCPMC12984537

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.