ArticlePakistan journal of medical sciences2026
Expression of lipid metabolism-related genes in hepatocellular carcinoma and their prognostic significance.
Article in Pakistan journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the expression profiles of key lipid metabolism-related genes in hepatocellular carcinoma(HCC) tissues, aiming to identify novel prognostic biomarkers for HCC. Methodology: This was a retrospective study. Sixty patients who underwent curative hepatectomy for HCC at the Affiliated Hospital of Hebei University between January 2022 to January 2025 were enrolled in this study. Immunohistochemistry was performed to assess the expression levels of SREBF1, FASN and ACLY in both HCC tissues and normal adjacent tissues(NATs). Expression differences between HCC tissues and NATs were compared. Clinical data were compared between the positive and negative groups. Kaplan-Meier survival curves were generated to evaluate overall survival (OS). Results: The positive expression rates of SREBF1, FASN and ACLY were significantly higher in HCC tissues compared with NATs(all Conclusion: The expression levels of the lipid metabolism-related genes SREBF1, FASN and ACLY are significantly elevated in HCC tissues compared with NATs. These genes are considered independent prognostic biomarkers in HCC.
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