ArticleFrontiers in aging2025
Emerging PFAS contaminants PFNA and PFSA amplify epigenetic aging: sex- and age-stratified risks in an aging population.
Article in Frontiers in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Per- and Polyfluoroalkyl Substances Exposure and Ischemic Heart Disease: Emerging Evidence from the Literature.Antioxidants (Basel, Switzerland) · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging perfluoroalkyl substances (PFAS), such as perfluorononanoic acid (PFNA) and perfluorosulfonic acid (PFSA), are pervasive environmental contaminants that may influence human health. Their effects on aging, particularly through recently developed robust DNA methylation (DNAm) aging algorithms, remain largely unexplored. Using data from 326 U.S. adults aged ≥50 years (NHANES 1999-2000), we quantified serum PFAS via isotope-dilution tandem mass spectrometry and computed 12 DNAm aging algorithms. Weighted multivariable linear regression models assessed PFAS-DNAm aging associations, stratified by sex and age. PFNA exposure was significantly associated with DNAm algorithms via GrimAgeMortacc (β = 2.74, 95% CI: 1.04-4.44) and GrimAge2Mortacc (β = 2.45, 0.60-4.31), with stronger magnitudes in males (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.