Evidence mapPaperPMID 41837155Full record

ArticleRSC advances2026

Simultaneous detection of thyroid-stimulating hormone and C-reactive protein using a multiplex lateral flow device for improved hypothyroidism diagnosis.

Sara E McNamee, Santosh Kumar Bikkarolla, Kerry-Louise Skillen, Deepesh Upadhyay, Mary Jo Kurth, Peter Fitzgerald, James McLaughlin

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Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sara E McNameeNanotechnology and Integrated Bioengineering Centre (NIBEC), School of Engineering, University of Ulster 2-24 York Street Belfast BT15 1AP UK.ORCID https://orcid.org/0000-0003-1711-2714
Santosh Kumar BikkarollaNanotechnology and Integrated Bioengineering Centre (NIBEC), School of Engineering, University of Ulster 2-24 York Street Belfast BT15 1AP UK.
Kerry-Louise SkillenNanotechnology and Integrated Bioengineering Centre (NIBEC), School of Engineering, University of Ulster 2-24 York Street Belfast BT15 1AP UK.
Deepesh UpadhyayRandox Laboratories Ltd 55 Diamond Road, Crumlin County Antrim BT29 4QY UK se.mcnamee@ulster.ac.uk.
Mary Jo KurthRandox Laboratories Ltd 55 Diamond Road, Crumlin County Antrim BT29 4QY UK se.mcnamee@ulster.ac.uk.
Peter FitzgeraldRandox Laboratories Ltd 55 Diamond Road, Crumlin County Antrim BT29 4QY UK se.mcnamee@ulster.ac.uk.
James McLaughlinNanotechnology and Integrated Bioengineering Centre (NIBEC), School of Engineering, University of Ulster 2-24 York Street Belfast BT15 1AP UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical and medical industries require practical and cost-effective solutions for simultaneous biomarker determination to replace time-consuming conventional testing methods. Hypothyroidism, or an underactive thyroid, occurs when your thyroid gland doesn't make enough thyroid hormones to meet your body's needs. Over time, hypothyroidism that isn't treated can lead to other health problems, such as high cholesterol and heart problems. This study introduces a novel, rapid, easy to use and portable multiplex lateral flow device (LFD) designed for the simultaneous detection of Thyroid stimulating hormone (TSH) and C-reactive protein (CRP) in human serum to aid in diagnosing hypothyroidism. Designed to meet the clinical need for hypothyroidism as well as rapid, cost-effective screening tools, the multiplex LFD delivers quantitative results within 30 minutes, showing detection limits of 2.1 µIU ml

Identifiers

PMID41837155
PMCPMC12980523

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.