Evidence map›Paper›PMID 41837642›Full record

ReviewJournal of virology2026

How new approach methods are reshaping virology research.

Min Liu, Jonathan G Faris, Amanda R Panfil, Cody J Warren

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Min LiuDepartment of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.ORCID 0009-0004-6585-1444
Jonathan G FarisDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado, USA.ORCID 0000-0003-2343-6520
Amanda R PanfilDepartment of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-8603-3705
Cody J WarrenDepartment of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-4101-2705

Funding

National Institute of Food and Agriculture 2025-39601-44639Swine Health Information Center #25-020
6 · The paper itself

Abstract

Animal models are a cornerstone of basic and translational virology research, widely used to study viral pathogenesis and evaluate vaccines and therapeutics. However, growing ethical and scientific concerns, alongside recent National Institutes of Health (NIH) and Food and Drug Administration (FDA) initiatives, are accelerating a shift toward non-animal, human-relevant alternatives. Advanced cell- and tissue-based systems now offer powerful platforms to model human disease. This Gem outlines emerging tools and highlights their promise for virology research in a rapidly evolving regulatory and technological landscape.

Indexed as

VirologyVirus DiseasesAnimalsDisease Models, AnimalHumansTranslational Research, BiomedicalUnited Stateshost-virus interactionsmodel systemsnew approach methods (NAMs)translational virology

Identifiers

PMID41837642
PMCPMC13098269

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.