Evidence map›Paper›PMID 41837671›Full record

ArticleJournal of Alzheimer's disease : JAD2026

Comparative effects of TDP-43-A and TDP-43-α on hippocampal subfields and amygdala nuclei.

Hossam Youssef, Rodolfo G Gatto, Nikhil B Ghayal, Ronald C Petersen, Clifford R Jack, R Ross Reichard, Dennis W Dickson, Jennifer L Whitwell, Keith A Josephs

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hossam YoussefDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID 0009-0000-8876-8038
Rodolfo G GattoDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-2170-6662
Nikhil B GhayalDepartment of Neuroscience (Neuropathology), Mayo Clinic, Jacksonville, FL, USA.
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
R Ross ReichardDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Dennis W DicksonDepartment of Neuroscience (Neuropathology), Mayo Clinic, Jacksonville, FL, USA.
Jennifer L WhitwellDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Keith A JosephsDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-2930-8634

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
Understanding the role of TDP-43 in Alzheimers disease and FTLDR01AG037491 · NIA · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2010 to 2024
$6.5M
NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG037491NIA NIH HHS U01 AG006786
6 · The paper itself

Abstract

Transactive response DNA-binding protein of 43 kDa (TDP-43) type-A is associated with frontotemporal lobar degeneration (FTLD). In primary age-related tauopathy (PART), TDP-type-α displays similar features to FTLD-TDP type-A. We compared antemortem MRI volumes of amygdala nuclei and hippocampal subfields between 16 PART-TDP-α and 12 FTLD-TDP-A autopsy-confirmed cases. Hippocampal tail and CA1 body volumes were smaller in PART-TDP-α group, which also had smaller lateral and central amygdala nuclei compared to FTLD-TDP-A group, but differences were non-significant after FDR correction. There is no evidence suggesting that TDP-43 type-A in FTLD affects hippocampal and amygdala volume loss differently than TDP-43 type-α in PART.

Indexed as

AmygdalaDNA-Binding ProteinsFrontotemporal Lobar DegenerationHippocampusAgedAged, 80 and overFemaleHumansMagnetic Resonance ImagingMaleDNA-Binding ProteinsTARDBP protein, humanAlzheimer's diseaseamygdala nucleifrontotemporal lobar degenerationhippocampal subfieldslimbic-predominant age-related TDP-43 encephalopathy (LATE_NC)primary age-related tauopathytransactive response DNA-binding protein of 43 kDa

Identifiers

PMID41837671
PMCPMC13151964

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.