ArticleJournal of gastroenterology2026
Steatosis index: a novel multiparametric ultrasound approach for accurate liver steatosis quantification and grading.
Article in Journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
aimsAccurate quantification of liver steatosis is critical for diagnosing steatotic liver disease. We aimed to evaluate a newly developed Steatosis Index (SI), which integrates multiple quantitative ultrasound (US) parameters, for assessing liver steatosis in patients with chronic liver disease (CLD).
methodsWe retrospectively enrolled 568 patients with CLD who underwent both US attenuation coefficient (iATT) and MRI-proton density fat fraction (PDFF). With MRI-PDFF as a reference standard, we examined whether SI, developed by integrating backscatter coefficient and signal texture parameters into iATT, improves the accuracy of liver steatosis quantification and grading.
resultsSI demonstrated a stronger correlation (Pearson's r = 0.85 vs. 0.78, p < 0.001) and better concordance (Lin's concordance correlation coefficient = 0.84 vs. 0.75, p < 0.001), as well as higher area under the receiver operating characteristic curve for differentiating each steatosis grade: 0.94 vs. 0.92 for grade ≥ 1, 0.95 vs. 0.90 for grade ≥ 2, and 0.93 vs. 0.88 for grade 3, all p < 0.001), compared to iATT. It also showed significant improvement in reclassification and discrimination metrics, with internal validation using bootstrap resampling confirming the reliability of these findings.
conclusionsSI provided excellent diagnostic performance in quantifying and grading liver steatosis and may serve as a valuable tool for monitoring it in patients with CLD. Trial Registration UMIN Clinical Trials Registry, Number: UMIN000047411.
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