Evidence map›Paper›PMID 41838778›Full record

ArticleThe journal of physical chemistry. B2026

Peptide-Functionalized Gold Nanorods as a Model to Reach the Cell Nucleus: Synthesis and Structural Characterizations in View of Theragnostic Applications.

Ludovica Binelli, Federica Bertelà, Simone Amatori, Diego Lipani, Chiara Battocchio, Giovanna Iucci, Luca Tortora, Valentina Dini, Sveva Grande, Alessandra Palma and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Ludovica BinelliSciences Department, Roma Tre University, 00146 Rome, Italy.
Federica BertelàSciences Department, Roma Tre University, 00146 Rome, Italy.
Simone AmatoriSciences Department, Roma Tre University, 00146 Rome, Italy.
Diego LipaniSciences Department, Roma Tre University, 00146 Rome, Italy.
Chiara BattocchioSciences Department, Roma Tre University, 00146 Rome, Italy.ORCID 0000-0003-4590-0865
Giovanna IucciSciences Department, Roma Tre University, 00146 Rome, Italy.ORCID 0000-0002-6478-3759
Luca TortoraSciences Department, Roma Tre University, 00146 Rome, Italy.ORCID 0000-0003-3053-2406
Valentina DiniNational Center for Innovative Technologies in Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Sveva GrandeNational Center for Innovative Technologies in Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Alessandra PalmaNational Center for Innovative Technologies in Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Marco RanaldiSciences Department, Roma Tre University, 00146 Rome, Italy.
Barbara De BerardisNational Center for Innovative Technologies in Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Maria G AmmendoliaNational Center for Innovative Technologies in Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Carlo Mancini-TerracianoIstituto Nazionale di Fisica Nucleare (INFN), Sezione di Roma1, Department of Physics, University La Sapienza, 00185 Rome, Italy.
Andrea FabbriIstituto Nazionale di Fisica Nucleare (INFN), Sezione di Roma3, Department of Sciences, Roma Tre University, 00146 Rome, Italy.
Andrea AttiliIstituto Nazionale di Fisica Nucleare (INFN), Sezione di Roma3, Department of Sciences, Roma Tre University, 00146 Rome, Italy.
Teresa ScotognellaNuclear Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Alessandro GiordanoNuclear Medicine Institute, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Maria L CalcagniNuclear Medicine Institute, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Monica DettinDepartment of Industrial Engineering, University of Padova, 35131 Padova, Italy.ORCID 0000-0002-6823-3375
Annj ZamunerDepartment of Industrial Engineering, University of Padova, 35131 Padova, Italy.ORCID 0000-0002-8113-0346
Valentin-Adrian MaraloiuNational Institute of Materials Physics, 077125 Magurele, Romania.ORCID 0000-0002-4400-5060
Iole VendittiSciences Department, Roma Tre University, 00146 Rome, Italy.ORCID 0000-0002-9306-573X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gold nanoparticles are proving to be highly successful for delivering drugs to specific targets, exploiting carefully designed functionalizations. This work creates and optimizes the synthesis of gold nanorods (AuNRs), subsequently functionalized with a peptide, TAT, appropriately modified to allow attachment to the rods and guide their entry into the cell nucleus and nuclear growth. Various chemical and physical characterizations were performed to verify and optimize the AuNRs-TAT system. DLS, Z-potential, UV-vis, and FT-IR spectroscopies confirmed the nanosize, monodispersity, colloidal stability, and successful functionalization. Furthermore, structural characterizations conducted using synchrotron radiation were crucial for understanding the actual interaction between the gold surface and the modified TAT peptide. The study highlighted how this material is indeed a good drug delivery system, stable over time, and promising for reaching the cell nucleus.

Indexed as

Cell NucleusGoldNanotubesPeptidesGoldPeptides

Identifiers

PMID41838778
PMCPMC13034408

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.