Evidence map›Paper›PMID 41838919›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Active maintenance of meiosis-specific chromosome structures in

Liesl G Strand, Charlotte P Choi, Savannah McCoy, Emmanuel T Nsamba, Nicola Silva, Anne M Villeneuve

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Active maintenance of meiosis-specific chromosome structures inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Liesl G StrandDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
Charlotte P ChoiDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
Savannah McCoyDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
Emmanuel T NsambaDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
Nicola SilvaDepartment of Biology, Masaryk University, Faculty of Medicine, Brno 625 000, Czech Republic.ORCID 0000-0001-5406-2280
Anne M VilleneuveDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.

Funding

GENETICS TRAINING PROGRAM FOR PHD CANDIDATEST32GM007790 · NIGMS · STANFORD UNIVERSITY · PI BRUNET, ANNE, KINGSLEY, DAVID M · 1985 to 2020
$12.8M
Meiotic Chromosome Inheritance in C. elegansR35GM126964 · NIGMS · STANFORD UNIVERSITY · PI ANNE M VILLENEUVE · 2018 to 2026
$6.2M
American Cancer Society (ACS) RP-15-209-01-DDCCzech Science Foundation GA23-04918SHHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM126964HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32GM007790
6 · The paper itself

Abstract

Meiotic prophase is characterized by a dynamic program in which germ cells undergo a complex series of associations and dissociations of protein complexes that drive assembly, remodeling, and disassembly of meiosis-specific chromosome structures and dramatic changes in chromosome compaction. Failure to properly coordinate these processes can result in improper chromosome segregation, producing aneuploid gametes and inviable zygotes. Here, we investigate the roles of

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsChromosomesMeiosisUbiquitin-Specific ProteasesAnimalsChromosomal Proteins, Non-HistoneChromosome SegregationCohesinsMutationSynaptonemal ComplexCaenorhabditis elegans ProteinsChromosomal Proteins, Non-HistoneCohesinsUbiquitin-Specific ProteasesC. eleganschromosome structuremeiosissynaptonemal complex

Identifiers

PMID41838919
PMCPMC13012089

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.