Evidence map›Paper›PMID 41839684›Full record

ArticleJournal, genetic engineering & biotechnology2026

Dual targeting of IGF-1R and K-RAS with natural phytochemicals for lung cancer therapy: an in-silico study.

Sk Faisal Ahmed, Zubaer Hossen, Indira Chakraborty, Md Masudur Rahman Munna, Sanjarah Chowdhury, Anika Zaheen, Jhuma Tasmin, A B M Ashraful, Md Abrar Jahin, Md Hossain Ahmed

Abstract read
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In one paragraph

Article in Journal, genetic engineering & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sk Faisal AhmedDawn of Bioinformatics, Dhaka 1360, Bangladesh.
Zubaer HossenDepartment of Biotechnology and Genetic Engineering, Gopalganj Science and Technology University, Gopalganj 8105, Bangladesh.
Indira ChakrabortyDepartment of Microbiology, University of Kalyani, Nadia, West Bengal 741235, India.
Md Masudur Rahman MunnaDawn of Bioinformatics, Dhaka 1360, Bangladesh; Bangladesh Agricultural University, Mymensingh 2202, Bangladesh.
Sanjarah ChowdhuryFaculty of Biotechnology and Genetic Engineering, Sylhet Agricultural University, Sylhet 3100, Bangladesh.
Anika ZaheenDepartment of Biomedical Engineering, Military Institute of Science and Technology, Dhaka 1216, Bangladesh.
Jhuma TasminDepartment of Pharmacy, Jahangirnagar University, Dhaka 1342, Bangladesh.
A B M AshrafulDepartment of Pharmacy, R. P. Shaha University, Narayanganj 1400, Bangladesh.
Md Abrar JahinDepartment of Pharmacy, Jahangirnagar University, Dhaka 1342, Bangladesh.
Md Hossain AhmedDawn of Bioinformatics, Dhaka 1360, Bangladesh; Department of Biotechnology and Genetic Engineering, Gopalganj Science and Technology University, Gopalganj 8105, Bangladesh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer remains one of the leading causes of cancer-related mortality worldwide, and the limitations and adverse effects of conventional chemotherapy necessitate the exploration of alternative therapeutic strategies. In this study, we used in-silico methods to identify bioactive compounds from medicinal plants with potential anti-lung cancer activity. We aimed to find potential inhibitors for the prevention of lung cancer, which can target two important proteins-insulin-like growth factor receptor (IGF-1R) and Kirsten rat sarcoma viral oncogene homologue (KRAS). A library of 1584 phytochemicals derived from 12 medicinal plants was retrieved from the IMPPAT 2.0 database and virtually screened using PyRx 0.8 software. According to the results, 17Beta-Hydroxywithanolide K and Ginkgolide A demonstrated strong binding affinity to IGF-1R (-9.4 Kcal/mol) and KRAS (-6.9 Kcal/mol), respectively, compared to the synthetic inhibitors Picropodophyllin (-7.7 Kcal/mol) and Sotorasib (-5.9 Kcal/mol). Pharmacokinetic (ADME) and toxicity analysis indicated favorable characteristics, including high gastrointestinal absorption and non-toxicity. Molecular dynamics (MD) simulations of 100 ns duration confirmed the stability of the protein-ligand complex. Overall, 17Beta-Hydroxywithanolide K and Ginkgolide A have potential as natural therapeutic agents for the treatment of lung cancer. However, additional in vitro and in vivo experiments are needed to validate these computational results.

Indexed as

ADMETKRASLung cancerMolecular dockingMolecular dynamics simulation

Identifiers

PMID41839684
PMCPMC12914188

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.