ArticleJournal, genetic engineering & biotechnology2026
Propolis alleviates brain tissue damage and oxidative abnormalities in streptozotocin (STZ)-induced diabetes.
Article in Journal, genetic engineering & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes is a serious and rapidly growing global health issue that can affect many organs, including the brain. It is often linked to complications such as cardiovascular disease and cerebral ischemia. Propolis, a natural resin produced by honey bees, is rich in phenols and flavonoids known for their antioxidant, anti-inflammatory, and immune-modulating properties.
objectiveThis primary aim in this research was to evaluate the neuroprotective effects of propolis on brain tissue in rats that have diabetes which is introduced through nicotinamide (NA) and streptozotocin (STZ).
methodsMale Wistar rats were separated into categories. Except for the control category, all were fed a diet that had high fat levels. Diabetes was induced using intraperitoneal injections of NA and STZ. After induction, diabetic rats received oral propolis at doses of 50 or 100 mg/kg daily for eight weeks. Throughout the study, lipid profiles, fasting blood glucose, insulin levels, and oxidative stress markers were assessed by taking measurements. At the end of the experiment, brain tissues were analyzed for cytokine levels, antioxidant activity, and DNA damage using the COMET assay, in addition to histopathological and immunohistochemical examinations.
resultsTreatment with propolis significantly reduced fasting blood glucose and insulin levels, improved profiles of lipid, and decreased oxidative stress and inflammatory mediators. Histological analysis showed that rats treated with propolis had noticeably less brain tissue damage compared to untreated diabetic rats.
conclusionPropolis demonstrated clear neuroprotective effects in diabetic rats, likely through its antioxidant and anti-inflammatory mechanisms. These findings suggest that propolis may present a considerably potential solution as a natural therapeutic agent for reducing diabetes-induced brain damage.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.