Observational studyPharmaceutical research2026
Impact of Postnatal Changes in Creatinine Levels on Plasma Gentamicin Concentrations in Neonates.
Observational study in Pharmaceutical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
objectiveGentamicin (GM), a renally eliminated drug, is widely used to treat infections in neonates. Neonatal dosing is typically based on body weight and postmenstrual age (PMA). Although serum creatinine (Cr) is the gold standard for evaluating renal function, Cr at birth may reflect both neonatal and maternal levels. This study aimed to identify determinants of trough GM concentrations, focusing on renal function parameters.
methodsThis retrospective, single-center, observational study included 78 neonates who started intravenous GM on postnatal days 0-1. Dosing regimen was stratified by birth weight: < 1200 g (n = 22), 5 mg/kg every 48 h; 1200-1999 g (n = 10), 4 mg/kg every 36 h; ≥ 2000 g (n = 46), 4 mg/kg every 24 h. Dose-normalized trough concentration (C/D) was calculated by dividing trough GM concentration by 24-h equivalent GM dose. Cr level measured at birth (Cr
resultsIn neonates < 1200 g and 1200-1999 g, Cr
conclusionPMA-based dosing appears to be preferable for determining initial GM dosing on postnatal day 0, whereas Cr-based renal function parameters may be more effective for guiding maintenance dosing.
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