Effects of Metabolic and Bariatric Surgery on Serum Uric Acid and its Association with Renal Function, and Visceral Adiposity: A Systematic Review and Meta-Analysis.

Delaram Moosavi, Seyed Mohammad Mehdi Khadem, Nogol Motamed-Gorji, Seyed Arash Javadmoosavi, Shahab Shahabi

Abstract readSystematic ReviewMeta-AnalysisReview

In one paragraph

Synthesis in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Delaram MoosaviMinimally Invasive Surgery Research Center, Tehran, Iran.

Seyed Mohammad Mehdi KhademMinimally Invasive Surgery Research Center, Tehran, Iran. smmehdikhadem@gmail.com.

Nogol Motamed-GorjiColorectal Research Center, Tehran, Iran.

Seyed Arash JavadmoosaviIran University of Medical Sciences, Tehran, Iran.

Shahab ShahabiMinimally Invasive Surgery Research Center, Tehran, Iran. shshahabi@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is associated with hyperuricemia through visceral adiposity, inflammation, and impaired renal urate handling. We systematically reviewed PubMed, Embase, Scopus, and Web of Science (January 2025) and meta-analyzed longitudinal changes in serum uric acid (SUA) after metabolic and bariatric surgery (MBS) and associations with creatinine (Cr), blood urea nitrogen (BUN), and waist circumference (WC). Forty-two studies (n = 9,468) were included and assessed using the Newcastle–Ottawa Scale. SUA showed a transient, non-significant rise at 7 days, then declined progressively, with the greatest reduction at 12 months (MD − 1.43 mg/dL; 95% CI − 1.80 to − 1.07). Reductions were larger after Roux-en-Y gastric bypass than sleeve gastrectomy. Meta-regression showed positive associations of postoperative SUA with Cr, WC, and BMI, but not BUN. MBS is associated with sustained urate reduction linked to renal and visceral adiposity improvements.

Indexed as

Bariatric SurgeryIntra-Abdominal FatKidneyUric AcidAdiposityHumansHyperuricemiaUric AcidMetabolic and bariatric surgeryRenal functionSerum uric acidVisceral adiposity

Identifiers

PMID41840314

DOI10.1177/2054358119884903

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.