ArticleThe Journal of physiology2026
Oxygen and glucose supplementation increases rates of linear growth and cell proliferation in growth-restricted fetal sheep.
Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Correction of hypoxemia and hypoglycemia restores muscle mitochondrial respiration and remodels mitochondrial proteome in growth-restricted sheep fetuses.American journal of physiology. Endocrinology and metabolism · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Placental insufficiency lowers oxygen and glucose concentrations in the fetus, which causes fetal growth restriction (FGR). Previously we showed that FGR fetuses chronically supplemented with oxygen and glucose (OG) have improved glucose tolerance. However growth was not evaluated. Here we test the hypothesis that sustained OG supplementation to an FGR fetus will increase linear growth rates, raise anabolic hormone concentrations and promote proliferation rates in pancreatic β-cells and skeletal muscle satellite cells, which are two tissues involved in glucose regulation. FGR was induced in sheep with environmental hyperthermia. FGR fetuses were chronically supplemented with either oxygen and glucose (FOG) or air and saline (FAS) for 10 days and compared to thermoneutral controls. Before supplementation both FOG and FAS fetuses had lower arterial oxygen, glucose, insulin and insulin-like growth factor 1 (IGF-1) concentrations compared to controls. The OG supplementation successfully increased PaO
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Registered trials
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