SynthesisBMC endocrine disorders2026
The effect of metabolic bariatric surgery on Anti-Müllerian hormone levels: a systematic review and meta-regression analysis.
Synthesis in BMC endocrine disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
backgroundThe possible anti-Mullerian hormone (AMH)-reduction impact of metabolic bariatric surgery has been assessed in a number of interventional investigations. The outcomes are still incongruous, however. This research sought to thoroughly examine the effects of metabolic bariatric surgery on AMH in order to have a better understanding of them.
methodsUsing standard keywords, the Scopus, PubMed/Medline, Web of Science, Cochrane, and Embase databases were searched to find all eligible human studies, including observational cohorts and single-arm pre–post studies, examining the levels of AMH after metabolic bariatric surgery treatment. For the best result estimate, random-effects model analysis produced 95% confidence intervals and a pooled weighted mean difference.
resultsThis article includes 15 treatment arms with a total of 459 participants. The results from the random-effects meta-analysis showed a significant reduction in AMH levels in the included observational and pre–post studies, with a pooled weighted mean difference (WMD) of −0.58 ng/ml [95% confidence interval (CI): −1.10 to −0.06; p = 0.028]. Subgroup analysis indicated that metabolic bariatric surgery had a greater effect on AMH reduction in the population with PCOS, with a time after the intervention of 48 weeks or longer, and in participants aged 30 years or younger compared to other groups.
conclusionsThis meta-analysis suggests that metabolic bariatric surgery is associated with reductions in AMH, particularly in women with PCOS. However, due to high heterogeneity, low-quality evidence, and lack of fertility outcomes, these results should be interpreted with caution. The implications for fertility remain uncertain.
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