Evidence map›Paper›PMID 41840717›Full record

ArticleThe Korean journal of pain2026

Manipulation therapy alleviates neuropathic pain

Liping Wu, Xiang Wang, Peng Yang, Xiongjiang Wang, Yujiao Zheng, Yeni Tang, Haoxin Zheng, Peng Ning, Hongliang Tang

Abstract read
In one paragraph

Article in The Korean journal of pain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liping WuThe First Clinical Medical College, Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region, China.ORCID https://orcid.org/0009-0007-8844-654X
Xiang WangDepartment of Medicine, Saines College of New Medicine, Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region, China.ORCID https://orcid.org/0009-0006-3460-666X
Peng YangDepartment of Tuina, Fangchenggang Hospital, Guangxi University of Chinese Medicine, Fangchenggang, Guangxi Zhuang Autonomous Region, China.ORCID https://orcid.org/0000-0003-2904-4202
Xiongjiang WangThe First Clinical Medical College, Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region, China.ORCID https://orcid.org/0009-0004-1476-4770
Yujiao ZhengThe First Clinical Medical College, Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region, China.ORCID https://orcid.org/0009-0003-2609-4826
Yeni TangThe First Clinical Medical College, Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region, China.ORCID https://orcid.org/0009-0007-3295-3657
Haoxin ZhengThe First Clinical Medical College, Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region, China.ORCID https://orcid.org/0009-0002-8613-5864
Peng NingThe First Clinical Medical College, Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region, China.ORCID https://orcid.org/0009-0005-1863-6431
Hongliang TangDepartment of Tuina, Fangchenggang Hospital, Guangxi University of Chinese Medicine, Fangchenggang, Guangxi Zhuang Autonomous Region, China.ORCID https://orcid.org/0000-0002-3021-5585

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Manipulation therapy (MT) relieves pain in nervous system disorders by reducing inflammation. Although evidence suggests MT is beneficial for neuropathic pain (NP), its molecular mechanisms remain unclear. This study investigated whether MT could reverse NP-related epigenetic changes and elucidated the potential mechanisms of NP. Methods: An NP model was established Results: The outcomes indicated that MT significantly attenuated SNL-induced pain hypersensitivity. The therapeutic effects of MT were correlated with global m Conclusions: This study provides evidence that MT effectively ameliorates NP by modulating inflammation and RNA m

Indexed as

Epigenesis, GeneticInflammationMusculoskeletal ManipulationsNeuralgiaRNA MethylationSuppressor of Cytokine Signaling 1 ProteinToll-Like Receptor 4

Identifiers

PMID41840717
PMCPMC13058937

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.