Evidence map›Paper›PMID 41840829›Full record

ArticleThe Journal of international medical research2026

A multiomics Mendelian randomization study on PANoptosis-related genes and gastric cancer risk.

Yunliang Wang, Yujian Xia, Lin Weng, Jin Wang, Wenzi Meng, Jiahui Zhu, Xin Zhao, Xinguo Zhu

Abstract read
In one paragraph

Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yunliang WangDepartment of General Surgery, The First Affiliated Hospital of Soochow University, China.
Yujian XiaDepartment of General Surgery, The First Affiliated Hospital of Soochow University, China.
Lin WengDepartment of General Surgery, Suzhou Wuzhong Hospital of Traditional Chinese Medicine, China.
Jin WangDepartment of General Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou 215000, China.
Wenzi MengDepartment of General Surgery, The First Affiliated Hospital of Soochow University, China.
Jiahui ZhuDepartment of General Surgery, The First Affiliated Hospital of Soochow University, China.
Xin ZhaoDepartment of General Surgery, The First Affiliated Hospital of Soochow University, China.
Xinguo ZhuDepartment of General Surgery, The First Affiliated Hospital of Soochow University, China.ORCID 0009-0001-4053-3325

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveTo explore the potential involvement of PANoptosis-related genes in gastric cancer susceptibility through multiomics analyses.MethodsSummary-data-based Mendelian randomization was performed by integrating blood-derived methylation, gene expression, and protein quantitative trait loci data with genome-wide association study results. The findings were further evaluated in The Cancer Genome Atlas cohort, followed by protein-protein interaction analysis, drug prediction, and molecular docking.ResultsSummary-data-based Mendelian randomization and colocalization analyses identified several traits suggestively associated with gastric cancer risk. Genetically predicted higher expression of apoptosis and caspase activation inhibitor (

Indexed as

Apoptosis Regulatory ProteinsGenetic Predisposition to DiseaseStomach NeoplasmsDNA MethylationEpigenesis, GeneticGene Expression Regulation, NeoplasticGenome-Wide Association StudyHepatocyte Growth FactorHumansMendelian Randomization AnalysisMultiomicsPolymorphism, Single NucleotideProtein Phosphatase 2Quantitative Trait LociApoptosis Regulatory ProteinsHepatocyte Growth FactorProtein Phosphatase 2biomarkercandidate genesepigenetic regulationGastric cancergenetic susceptibilityPANoptosissummary-data–based Mendelian randomization

Identifiers

PMID41840829
PMCPMC13213094

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.